Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may hav...

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Veröffentlicht in:	Cell host & microbe 2020-03, Vol.27 (3), p.325-328
Hauptverfasser:	Wu, Aiping, Peng, Yousong, Huang, Baoying, Ding, Xiao, Wang, Xianyue, Niu, Peihua, Meng, Jing, Zhu, Zhaozhong, Zhang, Zheng, Wang, Jiangyuan, Sheng, Jie, Quan, Lijun, Xia, Zanxian, Tan, Wenjie, Cheng, Genhong, Jiang, Taijiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Betacoronavirus - classification China Coronavirus Infections - virology COVID-19 Genome, Viral Middle East Respiratory Syndrome Coronavirus Pandemics Phylogeny Pneumonia, Viral - virology SARS Virus SARS-CoV-2
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Zusammenfassung:	An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV. An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV.
ISSN:	1931-3128 1934-6069
DOI:	10.1016/j.chom.2020.02.001