Effects of Zinc Acetate on Serum Zinc Concentrations in Chronic Liver Diseases: a Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial and a Dose Adjustment Trial

The essential trace element zinc maintains liver functions. Liver diseases can alter overall zinc concentrations, and hypozincemia is associated with various hepatic pathologies. Modulating systemic zinc through dietary supplementation is potentially useful for liver diseases. We evaluated the usefu...

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Veröffentlicht in:	Biological trace element research 2020-05, Vol.195 (1), p.71-81
Hauptverfasser:	Katayama, Kazuhiro, Hosui, Atsushi, Sakai, Yoshiyuki, Itou, Minoru, Matsuzaki, Yasushi, Takamori, Yoriyuki, Hosho, Keiko, Tsuru, Tomomi, Takikawa, Yasuhiro, Michitaka, Kojiro, Ogawa, Eishin, Miyoshi, Yoko, Ito, Toshifumi, Ida, Shinobu, Hamada, Izumi, Miyoshi, Katsunori, Kodama, Hiroko, Takehara, Tetsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Acetic acid Aged Biochemistry Biomedical and Life Sciences Biotechnology Chronic Disease Cirrhosis Clinical trials Copper Dietary Supplements Double-Blind Method Double-blind studies Female Humans Life Sciences Liver Liver cirrhosis Liver diseases Liver Diseases - blood Liver Diseases - pathology Male Middle Aged Nutrient deficiency Nutrition Oncology Placebo effect Randomization Serum Trace elements Weaning Zinc Zinc - blood Zinc acetate Zinc Acetate - administration & dosage Zinc Acetate - blood
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Zusammenfassung:	The essential trace element zinc maintains liver functions. Liver diseases can alter overall zinc concentrations, and hypozincemia is associated with various hepatic pathologies. Modulating systemic zinc through dietary supplementation is potentially useful for liver diseases. We evaluated the usefulness of zinc (NPC-02; acetate formulation) supplementation. We conducted two NPC-02 studies on zinc-deficient patients (serum zinc
ISSN:	0163-4984 1559-0720
DOI:	10.1007/s12011-019-01851-y