Analysis of Selenoprotein Expression in Response to Dietary Selenium Deficiency During Pregnancy Indicates Tissue Specific Differential Expression in Mothers and Sex Specific Changes in the Fetus and Offspring

The human selenoproteome is comprised of ~25 genes, which incorporate selenium, in the form of selenocysteine, into their structure. Since it is well known that selenium is important to maternal health and foetal development during pregnancy, this study aimed at defining the impact of selenium defic...

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Veröffentlicht in:	International journal of molecular sciences 2020-03, Vol.21 (6), p.2210
Hauptverfasser:	Hofstee, Pierre, Cuffe, James S M, Perkins, Anthony V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers Diet Embryos Female Females Fetus Fetuses Gene expression Gene Expression Regulation Gene regulation Gestation Heart Homeostasis Kidneys Liver Male Mice Mothers Muscles Organ Specificity - genetics Physiology Placenta Placenta - metabolism Pregnancy Selenium Selenium - deficiency Selenocysteine Selenoproteins Selenoproteins - genetics Sex Factors Sexual dimorphism Thyroid gland Transcription
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Beschreibung
Zusammenfassung:	The human selenoproteome is comprised of ~25 genes, which incorporate selenium, in the form of selenocysteine, into their structure. Since it is well known that selenium is important to maternal health and foetal development during pregnancy, this study aimed at defining the impact of selenium deficiency on maternal, placental, foetal and offspring selenoprotein gene expression. Female mice were randomly allocated to control (>190 μg/kg) or low selenium (
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms21062210