Antibiotic antagonist: the curious career of René Dubos

Only rarely do historians mention another miracle drug, gramicidin, and the Rockefeller researcher who discovered it, René Dubos. To some extent this is understandable: despite being hailed in 1939 as a "hundred thousand times" more powerful than the sulpha drugs, gramicidin proved highly...

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Veröffentlicht in:The Lancet (British edition) 2016-01, Vol.387 (10014), p.118-119
1. Verfasser: Honigsbaum, Mark
Format: Artikel
Sprache:eng
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Zusammenfassung:Only rarely do historians mention another miracle drug, gramicidin, and the Rockefeller researcher who discovered it, René Dubos. To some extent this is understandable: despite being hailed in 1939 as a "hundred thousand times" more powerful than the sulpha drugs, gramicidin proved highly toxic when administered intravenously and although it was widely used during World War 2 to treat wounds and other topical infections it was soon eclipsed by streptomycin.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(15)00840-5