Evolutionary selection of personalized melanoma cell/tissue dual-homing peptides for guiding bionanofibers to malignant tumors

Both melanoma cells and tissues were allowed to interact with an identical pool of billions of human-safe phage nanofiber clones with each genetically displaying a unique 12-mer peptide at the tips, respectively, resulting in the discovery of bionanofibers displaying a melanoma cell/tissue dual-homi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2018-02, Vol.54 (13), p.1631-1634
Hauptverfasser:	Yang, Mingying, Li, Yan, Huai, Yanyan, Wang, Chenyuan, Yi, Wenfang, Mao, Chuanbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bacteriophage M13 - chemistry Bacteriophage M13 - metabolism Cell Line, Tumor Chlorophyll - analogs & derivatives Chlorophyll - therapeutic use Drug Carriers - chemistry Drug Carriers - metabolism Drug Carriers - pharmacology Female Homing Humans Light Melanocytes - metabolism Melanoma Melanoma - metabolism Melanoma - therapy Mice, Inbred BALB C Nanofibers Nanofibers - chemistry Peptide Library Peptides Peptides - chemistry Peptides - metabolism Peptides - pharmacology Phages Photochemotherapy - methods Photosensitizing Agents - therapeutic use Protein Binding Tips Viral Proteins - chemistry Viral Proteins - metabolism Viral Proteins - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Both melanoma cells and tissues were allowed to interact with an identical pool of billions of human-safe phage nanofiber clones with each genetically displaying a unique 12-mer peptide at the tips, respectively, resulting in the discovery of bionanofibers displaying a melanoma cell/tissue dual-homing peptide for personalized targeted melanoma therapy.
ISSN:	1359-7345 1364-548X 1364-548X
DOI:	10.1039/c7cc09077c