MULTICENTRE DOUBLE-BLIND STUDY OF EFFECT OF INTRATHECALLY ADMINISTERED NATURAL HUMAN FIBROBLAST INTERFERON ON EXACERBATIONS OF MULTIPLE SCLEROSIS

In this randomised, double-blind, placebo-controlled, 2-year multicentre study intrathecally administered natural human fibroblast interferon (IFN-B) was effective in reducing exacerbations of multiple sclerosis (MS) in patients with exacerbating/remitting disease. The mean reduction in exacerbation...

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Veröffentlicht in:	The Lancet (British edition) 1986-12, Vol.328 (8521-8522), p.1411-1413
Hauptverfasser:	Jacobs, Lawrence, Herndon, Robert, Freeman, Arnold, Cuetter, Albert, Smith, WilliamA, Salazar, AndresM, Reese, PeterA, Josefowicz, Ralph, Husain, Farhat, Ekes, Roslyn, O'Malley, JudithA
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Biological and medical sciences Clinical Trials as Topic Double-Blind Method Double-blind studies Fibroblasts Follow-Up Studies Humans Indomethacin Indomethacin - administration & dosage Injections, Spinal Interferon Interferon Type I - administration & dosage Medical sciences Miscellaneous Multiple sclerosis Multiple Sclerosis - therapy Neuropharmacology Patients Pharmacology. Drug treatments Random Allocation Toxicity
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Zusammenfassung:	In this randomised, double-blind, placebo-controlled, 2-year multicentre study intrathecally administered natural human fibroblast interferon (IFN-B) was effective in reducing exacerbations of multiple sclerosis (MS) in patients with exacerbating/remitting disease. The mean reduction in exacerbation rate of 34 patients who received IFN-B (recipients) was significantly greater during the study than that of 35 patients who received placebo (p
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(86)92730-3