From Prior Information to Saccade Selection: Evolution of Frontal Eye Field Activity during Natural Scene Search
Abstract Prior knowledge about our environment influences our actions. How does this knowledge evolve into a final action plan and how does the brain represent this? Here, we investigated this question in the monkey oculomotor system during self-guided search of natural scenes. In the frontal eye fi...
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Veröffentlicht in: | Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2020-03, Vol.30 (3), p.1957-1973 |
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container_end_page | 1973 |
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container_issue | 3 |
container_start_page | 1957 |
container_title | Cerebral cortex (New York, N.Y. 1991) |
container_volume | 30 |
creator | Glaser, Joshua I Wood, Daniel K Lawlor, Patrick N Segraves, Mark A Kording, Konrad P |
description | Abstract
Prior knowledge about our environment influences our actions. How does this knowledge evolve into a final action plan and how does the brain represent this? Here, we investigated this question in the monkey oculomotor system during self-guided search of natural scenes. In the frontal eye field (FEF), we found a subset of neurons, “Early neurons,” that contain information about the upcoming saccade long before it is executed, often before the previous saccade had even ended. Crucially, much of this early information did not relate to the actual saccade that would eventually be selected. Rather, it related to prior information about the probabilities of possible upcoming saccades based on the presaccade fixation location. Nearer to the time of saccade onset, a greater proportion of these neurons’ activities related to the saccade selection, although prior information continued to influence activity throughout. A separate subset of FEF neurons, “Late neurons,” only represented the final action plan near saccade onset and not prior information. Our results demonstrate how, across the population of FEF neurons, prior information evolves into definitive saccade plans. |
doi_str_mv | 10.1093/cercor/bhz216 |
format | Article |
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Prior knowledge about our environment influences our actions. How does this knowledge evolve into a final action plan and how does the brain represent this? Here, we investigated this question in the monkey oculomotor system during self-guided search of natural scenes. In the frontal eye field (FEF), we found a subset of neurons, “Early neurons,” that contain information about the upcoming saccade long before it is executed, often before the previous saccade had even ended. Crucially, much of this early information did not relate to the actual saccade that would eventually be selected. Rather, it related to prior information about the probabilities of possible upcoming saccades based on the presaccade fixation location. Nearer to the time of saccade onset, a greater proportion of these neurons’ activities related to the saccade selection, although prior information continued to influence activity throughout. A separate subset of FEF neurons, “Late neurons,” only represented the final action plan near saccade onset and not prior information. Our results demonstrate how, across the population of FEF neurons, prior information evolves into definitive saccade plans.</description><identifier>ISSN: 1047-3211</identifier><identifier>EISSN: 1460-2199</identifier><identifier>DOI: 10.1093/cercor/bhz216</identifier><identifier>PMID: 31647525</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Action Potentials - physiology ; Animals ; Attention - physiology ; Fixation, Ocular - physiology ; Frontal Lobe - physiology ; Memory - physiology ; Neurons - physiology ; Original ; Photic Stimulation - methods ; Reaction Time - physiology ; Visual Fields - physiology ; Visual Perception - physiology</subject><ispartof>Cerebral cortex (New York, N.Y. 1991), 2020-03, Vol.30 (3), p.1957-1973</ispartof><rights>The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com. 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-e46583aaec9b38285e311d75b4cf4905eaf5f58618ad0acb89dd11f3bdddc0443</citedby><cites>FETCH-LOGICAL-c420t-e46583aaec9b38285e311d75b4cf4905eaf5f58618ad0acb89dd11f3bdddc0443</cites><orcidid>0000-0003-2906-115X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31647525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Glaser, Joshua I</creatorcontrib><creatorcontrib>Wood, Daniel K</creatorcontrib><creatorcontrib>Lawlor, Patrick N</creatorcontrib><creatorcontrib>Segraves, Mark A</creatorcontrib><creatorcontrib>Kording, Konrad P</creatorcontrib><title>From Prior Information to Saccade Selection: Evolution of Frontal Eye Field Activity during Natural Scene Search</title><title>Cerebral cortex (New York, N.Y. 1991)</title><addtitle>Cereb Cortex</addtitle><description>Abstract
Prior knowledge about our environment influences our actions. How does this knowledge evolve into a final action plan and how does the brain represent this? Here, we investigated this question in the monkey oculomotor system during self-guided search of natural scenes. In the frontal eye field (FEF), we found a subset of neurons, “Early neurons,” that contain information about the upcoming saccade long before it is executed, often before the previous saccade had even ended. Crucially, much of this early information did not relate to the actual saccade that would eventually be selected. Rather, it related to prior information about the probabilities of possible upcoming saccades based on the presaccade fixation location. Nearer to the time of saccade onset, a greater proportion of these neurons’ activities related to the saccade selection, although prior information continued to influence activity throughout. A separate subset of FEF neurons, “Late neurons,” only represented the final action plan near saccade onset and not prior information. Our results demonstrate how, across the population of FEF neurons, prior information evolves into definitive saccade plans.</description><subject>Action Potentials - physiology</subject><subject>Animals</subject><subject>Attention - physiology</subject><subject>Fixation, Ocular - physiology</subject><subject>Frontal Lobe - physiology</subject><subject>Memory - physiology</subject><subject>Neurons - physiology</subject><subject>Original</subject><subject>Photic Stimulation - methods</subject><subject>Reaction Time - physiology</subject><subject>Visual Fields - physiology</subject><subject>Visual Perception - physiology</subject><issn>1047-3211</issn><issn>1460-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtr3DAURkVpyatZdlu07MaJrh5-dFEIw0wSCE1g0rWQpeuMim1NZXtg8uujyeTRrrqS0D0694OPkC_AzoBV4txitCGe16tHDvkHcgQyZxmHqvqY7kwWmeAAh-R4GH4zBgVX_IAcCshlobg6IutFDB29iz5Eet03IXZm9KGnY6BLY61xSJfYot09fqfzTWin53loaPrZj6al8y3ShcfW0YuEbfy4pW6Kvn-gP804xUQsLfY7j4l29Zl8akw74OnLeUJ-Leb3s6vs5vbyenZxk1nJ2ZihzFUpjEFb1aLkpUIB4ApVS9vIiik0jWpUmUNpHDO2LivnABpRO-csk1KckB9773qqO3QpwZii6HX0nYlbHYzX_056v9IPYaMLELziVRJ8exHE8GfCYdSdHyy2rekxTIPmgpUKShB5QrM9amMYhojN2xpgeteS3rek9y0l_uvf2d7o11red4dp_R_XE7fHoGA</recordid><startdate>20200314</startdate><enddate>20200314</enddate><creator>Glaser, Joshua I</creator><creator>Wood, Daniel K</creator><creator>Lawlor, Patrick N</creator><creator>Segraves, Mark A</creator><creator>Kording, Konrad P</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2906-115X</orcidid></search><sort><creationdate>20200314</creationdate><title>From Prior Information to Saccade Selection: Evolution of Frontal Eye Field Activity during Natural Scene Search</title><author>Glaser, Joshua I ; Wood, Daniel K ; Lawlor, Patrick N ; Segraves, Mark A ; Kording, Konrad P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-e46583aaec9b38285e311d75b4cf4905eaf5f58618ad0acb89dd11f3bdddc0443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Action Potentials - physiology</topic><topic>Animals</topic><topic>Attention - physiology</topic><topic>Fixation, Ocular - physiology</topic><topic>Frontal Lobe - physiology</topic><topic>Memory - physiology</topic><topic>Neurons - physiology</topic><topic>Original</topic><topic>Photic Stimulation - methods</topic><topic>Reaction Time - physiology</topic><topic>Visual Fields - physiology</topic><topic>Visual Perception - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Glaser, Joshua I</creatorcontrib><creatorcontrib>Wood, Daniel K</creatorcontrib><creatorcontrib>Lawlor, Patrick N</creatorcontrib><creatorcontrib>Segraves, Mark A</creatorcontrib><creatorcontrib>Kording, Konrad P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Glaser, Joshua I</au><au>Wood, Daniel K</au><au>Lawlor, Patrick N</au><au>Segraves, Mark A</au><au>Kording, Konrad P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>From Prior Information to Saccade Selection: Evolution of Frontal Eye Field Activity during Natural Scene Search</atitle><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle><addtitle>Cereb Cortex</addtitle><date>2020-03-14</date><risdate>2020</risdate><volume>30</volume><issue>3</issue><spage>1957</spage><epage>1973</epage><pages>1957-1973</pages><issn>1047-3211</issn><eissn>1460-2199</eissn><abstract>Abstract
Prior knowledge about our environment influences our actions. How does this knowledge evolve into a final action plan and how does the brain represent this? Here, we investigated this question in the monkey oculomotor system during self-guided search of natural scenes. In the frontal eye field (FEF), we found a subset of neurons, “Early neurons,” that contain information about the upcoming saccade long before it is executed, often before the previous saccade had even ended. Crucially, much of this early information did not relate to the actual saccade that would eventually be selected. Rather, it related to prior information about the probabilities of possible upcoming saccades based on the presaccade fixation location. Nearer to the time of saccade onset, a greater proportion of these neurons’ activities related to the saccade selection, although prior information continued to influence activity throughout. A separate subset of FEF neurons, “Late neurons,” only represented the final action plan near saccade onset and not prior information. Our results demonstrate how, across the population of FEF neurons, prior information evolves into definitive saccade plans.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>31647525</pmid><doi>10.1093/cercor/bhz216</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0003-2906-115X</orcidid><oa>free_for_read</oa></addata></record> |
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source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
subjects | Action Potentials - physiology Animals Attention - physiology Fixation, Ocular - physiology Frontal Lobe - physiology Memory - physiology Neurons - physiology Original Photic Stimulation - methods Reaction Time - physiology Visual Fields - physiology Visual Perception - physiology |
title | From Prior Information to Saccade Selection: Evolution of Frontal Eye Field Activity during Natural Scene Search |
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