Acquired pure red cell aplasia following recombinant erythropoietin (darbepoetin-alfa) therapy

Acquired pure red cell aplasia following recombinant erythropoietin (darbepoetin-alfa) therapy

Acquired pure red cell aplasia (PRCA) following use of recombinant erythropoietin (rEPO) is distinctly rare and sporadically reported in the literature. We discuss a case of PRCA following the usage of rEPO (darbepoetin-α) during the management of anemia of chronic kidney disease in an elderly male...

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Veröffentlicht in:Indian journal of nephrology 2020-03, Vol.30 (2), p.113-116
Hauptverfasser: Padhi, Somanath, Behera, Gayatri, Pattnaik, Sandeep, Das, Prabodh, Adhya, Amit, Patra, Susama
Format: Artikel
Sprache:eng
Schlagworte:
Age
Anemia
Biopsy
Bone marrow
Case Report
Chronic kidney failure
Clopidogrel
Cytogenetics
Darbepoetin alfa
Diseases
Elderly
Erythropoietin
Females
Glycoproteins
Hematology
Infections
Iron
Males
Neutrophils
Patients
Recombinant erythropoietin
Viral infections
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Zusammenfassung:Acquired pure red cell aplasia (PRCA) following use of recombinant erythropoietin (rEPO) is distinctly rare and sporadically reported in the literature. We discuss a case of PRCA following the usage of rEPO (darbepoetin-α) during the management of anemia of chronic kidney disease in an elderly male subject with review of literature and a brief insight into proposed pathophysiologic mechanism, diagnosis, and management.
ISSN:0971-4065
1998-3662
DOI:10.4103/ijn.ijn_129_19