Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen

Highlights • Serological, molecular and phylogenetic analysis of a recently imported case of MERS coronavirus (MERS-CoV) in Greece. • MERS-CoV remained detectable in the respiratory tract secretions of the patient until the fourth week of illness, whereas viraemia was last detected two days after th...

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Veröffentlicht in:International journal of antimicrobial agents 2014-12, Vol.44 (6), p.528-532
Hauptverfasser: Spanakis, Nikolaos, Tsiodras, Sotirios, Haagmans, Bart L, Raj, V. Stalin, Pontikis, Kostantinos, Koutsoukou, Antonia, Koulouris, Nikolaos G, Osterhaus, Albert D.M.E, Koopmans, Marion P.G, Tsakris, Athanassios
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Sprache:eng
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Zusammenfassung:Highlights • Serological, molecular and phylogenetic analysis of a recently imported case of MERS coronavirus (MERS-CoV) in Greece. • MERS-CoV remained detectable in the respiratory tract secretions of the patient until the fourth week of illness, whereas viraemia was last detected two days after the institution of the triple combination therapy. • The non-detectable viral RNA in serum by day 3 after the initiation of the antiviral treatment could be explained either by viral clearance in an otherwise immunocompetent person or by effectiveness of the instituted antiviral regimen.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2014.07.026