Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)

Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inh...

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Veröffentlicht in:	Life sciences (1973) 2006-01, Vol.78 (6), p.614-621
Hauptverfasser:	Wang, Ying, Zhang, Yingmei, Yang, Xue, Han, Wenling, Liu, Yanan, Xu, Qianmei, Zhao, Rui, Di, Chunhui, Song, Quansheng, Ma, Dalong
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - metabolism CCR4 Cells, Cultured Chemokine Chemokine CCL17 Chemokines - pharmacology Chemokines, CC - pharmacology Chemotaxis CLF Humans Ligand Ligands MARVEL Domain-Containing Proteins Receptors, CCR4 Receptors, Chemokine - metabolism Recombinant CKLF1 Recombinant Proteins - pharmacology TARC/CCL17 Transfection
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Zusammenfassung:	Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inhibited by PTX. CKLF1 induced a calcium flux in CCR4-transfected cells and fully desensitized a subsequent response to TARC/CCL17, and TARC/CCL17 could partly desensitize the response to CKLF1. CKLF1 caused significant receptor internalization in pCCR4-EGFP transfected cells. Taken together, CKLF1 is a novel functional ligand for CCR4.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/j.lfs.2005.05.070