Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond

Highlights • Bats are natural reservoirs of many coronaviruses that can infect humans. • Mechanisms of cross-species transmission of coronaviruses are important scientific questions. • The coronaviral spike protein is an important viral determinant of cross-species transmission. • Receptor-binding c...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 2015-08, Vol.23 (8), p.468-478
Hauptverfasser:	Lu, Guangwen, Wang, Qihui, Gao, George F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chiroptera Coronavirus Coronavirus Infections - transmission Coronavirus Infections - veterinary Host Specificity Humans Internal Medicine interspecies transmission MERS-CoV Middle East Respiratory Syndrome Coronavirus - genetics Middle East Respiratory Syndrome Coronavirus - physiology Protein Binding SARS coronavirus SARS Virus - genetics SARS Virus - physiology SARS-CoV spike (S) Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism viral and host determinants Viral Tropism Virus Internalization Zoonoses - transmission
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Beschreibung
Zusammenfassung:	Highlights • Bats are natural reservoirs of many coronaviruses that can infect humans. • Mechanisms of cross-species transmission of coronaviruses are important scientific questions. • The coronaviral spike protein is an important viral determinant of cross-species transmission. • Receptor-binding characteristics and cleavage priming of the spike protein are summarized.
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2015.06.003