A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector
Late blight caused by Phytophthora infestans greatly constrains potato production. Many Resistance (R) genes were cloned from wild Solanum species and/or introduced into potato cultivars by breeding. However, individual R genes have been overcome by P. infestans evolution; durable resistance remains...
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| Veröffentlicht in: | Nature plants 2021-02, Vol.7 (2), p.198-208 |
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| creator | Witek, Kamil Lin, Xiao Karki, Hari S. Jupe, Florian Witek, Agnieszka I. Steuernagel, Burkhard Stam, Remco van Oosterhout, Cock Fairhead, Sebastian Heal, Robert Cocker, Jonathan M. Bhanvadia, Shivani Barrett, William Wu, Chih-Hang Adachi, Hiroaki Song, Tianqiao Kamoun, Sophien Vleeshouwers, Vivianne G. A. A. Tomlinson, Laurence Wulff, Brande B. H. Jones, Jonathan D. G. |
| description | Late blight caused by
Phytophthora infestans
greatly constrains potato production. Many
Resistance (R)
genes were cloned from wild
Solanum
species and/or introduced into potato cultivars by breeding. However, individual
R
genes have been overcome by
P. infestans
evolution; durable resistance remains elusive. We positionally cloned a new
R
gene,
Rpi-amr1
, from
Solanum americanum
, that encodes an NRC helper-dependent CC-NLR protein.
Rpi-amr1
confers resistance in potato to all 19
P. infestans
isolates tested. Using association genomics and long-read RenSeq, we defined eight additional
Rpi-amr1
alleles from different
S. americanum
and related species. Despite only ~90% identity between Rpi-amr1 proteins, all confer late blight resistance but differentially recognize
Avramr1
orthologues and paralogues. We propose that
Rpi-amr1
gene family diversity assists detection of diverse paralogues and alleles of the recognized effector, facilitating durable resistance against
P. infestans
.
The authors apply state-of-the-art genomic approaches to characterize a novel late blight resistance gene in a wild Solanaceae. This gene, when expressed in cultivated potato, confers a broad and robust resistance to many
Phytophthora infestans
isolates. |
| doi_str_mv | 10.1038/s41477-021-00854-9 |
| format | Article |
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Phytophthora infestans
greatly constrains potato production. Many
Resistance (R)
genes were cloned from wild
Solanum
species and/or introduced into potato cultivars by breeding. However, individual
R
genes have been overcome by
P. infestans
evolution; durable resistance remains elusive. We positionally cloned a new
R
gene,
Rpi-amr1
, from
Solanum americanum
, that encodes an NRC helper-dependent CC-NLR protein.
Rpi-amr1
confers resistance in potato to all 19
P. infestans
isolates tested. Using association genomics and long-read RenSeq, we defined eight additional
Rpi-amr1
alleles from different
S. americanum
and related species. Despite only ~90% identity between Rpi-amr1 proteins, all confer late blight resistance but differentially recognize
Avramr1
orthologues and paralogues. We propose that
Rpi-amr1
gene family diversity assists detection of diverse paralogues and alleles of the recognized effector, facilitating durable resistance against
P. infestans
.
The authors apply state-of-the-art genomic approaches to characterize a novel late blight resistance gene in a wild Solanaceae. This gene, when expressed in cultivated potato, confers a broad and robust resistance to many
Phytophthora infestans
isolates.</description><identifier>EISSN: 2055-0278</identifier><identifier>DOI: 10.1038/s41477-021-00854-9</identifier><identifier>PMID: 33574576</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38 ; 45 ; 45/23 ; 45/41 ; 45/77 ; 45/91 ; 631/208/212 ; 631/208/2491 ; 631/208/711 ; 631/449/2169 ; 631/449/711 ; Alleles ; Biomedical and Life Sciences ; Chromosome Mapping ; Cloning ; Cloning, Molecular - methods ; Cultivars ; Disease resistance ; Disease Resistance - genetics ; Evolutionary genetics ; Gene Expression Regulation, Plant ; Genes ; Genes, Plant ; Genomics ; Introduced species ; Late blight ; Life Sciences ; Nlr protein ; Phytophthora infestans ; Phytophthora infestans - pathogenicity ; Plant breeding ; Plant Breeding - methods ; Plant Diseases - genetics ; Plant Immunity - genetics ; Plant Sciences ; Potatoes ; Proteins ; Solanum - genetics ; Solanum americanum ; Vegetables</subject><ispartof>Nature plants, 2021-02, Vol.7 (2), p.198-208</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-8284-7728 ; 0000-0002-5653-738X ; 0000-0003-0659-5562 ; 0000-0002-4953-261X ; 0000-0002-8160-4556 ; 0000-0003-4044-4346 ; 0000-0002-3848-0244 ; 0000-0002-0290-0315 ; 0000-0002-4946-6149 ; 0000-0002-3444-6954</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33574576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Witek, Kamil</creatorcontrib><creatorcontrib>Lin, Xiao</creatorcontrib><creatorcontrib>Karki, Hari S.</creatorcontrib><creatorcontrib>Jupe, Florian</creatorcontrib><creatorcontrib>Witek, Agnieszka I.</creatorcontrib><creatorcontrib>Steuernagel, Burkhard</creatorcontrib><creatorcontrib>Stam, Remco</creatorcontrib><creatorcontrib>van Oosterhout, Cock</creatorcontrib><creatorcontrib>Fairhead, Sebastian</creatorcontrib><creatorcontrib>Heal, Robert</creatorcontrib><creatorcontrib>Cocker, Jonathan M.</creatorcontrib><creatorcontrib>Bhanvadia, Shivani</creatorcontrib><creatorcontrib>Barrett, William</creatorcontrib><creatorcontrib>Wu, Chih-Hang</creatorcontrib><creatorcontrib>Adachi, Hiroaki</creatorcontrib><creatorcontrib>Song, Tianqiao</creatorcontrib><creatorcontrib>Kamoun, Sophien</creatorcontrib><creatorcontrib>Vleeshouwers, Vivianne G. A. A.</creatorcontrib><creatorcontrib>Tomlinson, Laurence</creatorcontrib><creatorcontrib>Wulff, Brande B. H.</creatorcontrib><creatorcontrib>Jones, Jonathan D. G.</creatorcontrib><title>A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector</title><title>Nature plants</title><addtitle>Nat. Plants</addtitle><addtitle>Nat Plants</addtitle><description>Late blight caused by
Phytophthora infestans
greatly constrains potato production. Many
Resistance (R)
genes were cloned from wild
Solanum
species and/or introduced into potato cultivars by breeding. However, individual
R
genes have been overcome by
P. infestans
evolution; durable resistance remains elusive. We positionally cloned a new
R
gene,
Rpi-amr1
, from
Solanum americanum
, that encodes an NRC helper-dependent CC-NLR protein.
Rpi-amr1
confers resistance in potato to all 19
P. infestans
isolates tested. Using association genomics and long-read RenSeq, we defined eight additional
Rpi-amr1
alleles from different
S. americanum
and related species. Despite only ~90% identity between Rpi-amr1 proteins, all confer late blight resistance but differentially recognize
Avramr1
orthologues and paralogues. We propose that
Rpi-amr1
gene family diversity assists detection of diverse paralogues and alleles of the recognized effector, facilitating durable resistance against
P. infestans
.
The authors apply state-of-the-art genomic approaches to characterize a novel late blight resistance gene in a wild Solanaceae. This gene, when expressed in cultivated potato, confers a broad and robust resistance to many
Phytophthora infestans
isolates.</description><subject>38</subject><subject>45</subject><subject>45/23</subject><subject>45/41</subject><subject>45/77</subject><subject>45/91</subject><subject>631/208/212</subject><subject>631/208/2491</subject><subject>631/208/711</subject><subject>631/449/2169</subject><subject>631/449/711</subject><subject>Alleles</subject><subject>Biomedical and Life Sciences</subject><subject>Chromosome Mapping</subject><subject>Cloning</subject><subject>Cloning, Molecular - methods</subject><subject>Cultivars</subject><subject>Disease resistance</subject><subject>Disease Resistance - genetics</subject><subject>Evolutionary genetics</subject><subject>Gene Expression Regulation, Plant</subject><subject>Genes</subject><subject>Genes, Plant</subject><subject>Genomics</subject><subject>Introduced species</subject><subject>Late blight</subject><subject>Life Sciences</subject><subject>Nlr protein</subject><subject>Phytophthora infestans</subject><subject>Phytophthora infestans - pathogenicity</subject><subject>Plant breeding</subject><subject>Plant Breeding - methods</subject><subject>Plant Diseases - genetics</subject><subject>Plant Immunity - genetics</subject><subject>Plant Sciences</subject><subject>Potatoes</subject><subject>Proteins</subject><subject>Solanum - genetics</subject><subject>Solanum americanum</subject><subject>Vegetables</subject><issn>2055-0278</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVkU9rGzEQxUUhxMHJF-ihCHLeZFZ_VtpLwZi0DQRSaHMsQpZn7Q270kbaNXE-fZXYTduLNMw8_Ua8R8jHEq5K4Po6iVIoVQArCwAtRVF_IGcMpMwtpWfkIqVHACiVlLyCUzLjXCohVXVGfi2oC_3Q4TONmNo0Wu-QdsFNibae_gid9VNPbY-xdW9lRBc2vn3BRG1-6xPGHa7p9-1-DMN23IZoKTYNujHEc3LS2C7hxfGek4cvNz-X34q7-6-3y8VdMTAux2LNLGrBG9aoFeSCrRrNpRASFNNYVwKEZkxLroCxfFpXg167RgtQTSWQz8nnA3eYVj2uHfox2s4Mse1t3JtgW_P_xLdbswk7o8qyUppnwOUREMPThGk0j2GKPv_ZMKHrGqrsa1Z9-nfNO_-PnVnAD4KUR36D8S-mBPOalTlkZXJW5i0rU_PfCRGHZg</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Witek, Kamil</creator><creator>Lin, Xiao</creator><creator>Karki, Hari S.</creator><creator>Jupe, Florian</creator><creator>Witek, Agnieszka I.</creator><creator>Steuernagel, Burkhard</creator><creator>Stam, Remco</creator><creator>van Oosterhout, Cock</creator><creator>Fairhead, Sebastian</creator><creator>Heal, Robert</creator><creator>Cocker, Jonathan M.</creator><creator>Bhanvadia, Shivani</creator><creator>Barrett, William</creator><creator>Wu, Chih-Hang</creator><creator>Adachi, Hiroaki</creator><creator>Song, Tianqiao</creator><creator>Kamoun, Sophien</creator><creator>Vleeshouwers, Vivianne G. A. A.</creator><creator>Tomlinson, Laurence</creator><creator>Wulff, Brande B. H.</creator><creator>Jones, Jonathan D. G.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7SN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8284-7728</orcidid><orcidid>https://orcid.org/0000-0002-5653-738X</orcidid><orcidid>https://orcid.org/0000-0003-0659-5562</orcidid><orcidid>https://orcid.org/0000-0002-4953-261X</orcidid><orcidid>https://orcid.org/0000-0002-8160-4556</orcidid><orcidid>https://orcid.org/0000-0003-4044-4346</orcidid><orcidid>https://orcid.org/0000-0002-3848-0244</orcidid><orcidid>https://orcid.org/0000-0002-0290-0315</orcidid><orcidid>https://orcid.org/0000-0002-4946-6149</orcidid><orcidid>https://orcid.org/0000-0002-3444-6954</orcidid></search><sort><creationdate>20210201</creationdate><title>A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector</title><author>Witek, Kamil ; Lin, Xiao ; Karki, Hari S. ; Jupe, Florian ; Witek, Agnieszka I. ; Steuernagel, Burkhard ; Stam, Remco ; van Oosterhout, Cock ; Fairhead, Sebastian ; Heal, Robert ; Cocker, Jonathan M. ; Bhanvadia, Shivani ; Barrett, William ; Wu, Chih-Hang ; Adachi, Hiroaki ; Song, Tianqiao ; Kamoun, Sophien ; Vleeshouwers, Vivianne G. A. A. ; Tomlinson, Laurence ; Wulff, Brande B. H. ; Jones, Jonathan D. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-d2ae843f2f7b08432bf8354450728e964048228537022537ac908dcf8407f64e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>38</topic><topic>45</topic><topic>45/23</topic><topic>45/41</topic><topic>45/77</topic><topic>45/91</topic><topic>631/208/212</topic><topic>631/208/2491</topic><topic>631/208/711</topic><topic>631/449/2169</topic><topic>631/449/711</topic><topic>Alleles</topic><topic>Biomedical and Life Sciences</topic><topic>Chromosome Mapping</topic><topic>Cloning</topic><topic>Cloning, Molecular - methods</topic><topic>Cultivars</topic><topic>Disease resistance</topic><topic>Disease Resistance - genetics</topic><topic>Evolutionary genetics</topic><topic>Gene Expression Regulation, Plant</topic><topic>Genes</topic><topic>Genes, Plant</topic><topic>Genomics</topic><topic>Introduced species</topic><topic>Late blight</topic><topic>Life Sciences</topic><topic>Nlr protein</topic><topic>Phytophthora infestans</topic><topic>Phytophthora infestans - pathogenicity</topic><topic>Plant breeding</topic><topic>Plant Breeding - methods</topic><topic>Plant Diseases - genetics</topic><topic>Plant Immunity - genetics</topic><topic>Plant Sciences</topic><topic>Potatoes</topic><topic>Proteins</topic><topic>Solanum - genetics</topic><topic>Solanum americanum</topic><topic>Vegetables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Witek, Kamil</creatorcontrib><creatorcontrib>Lin, Xiao</creatorcontrib><creatorcontrib>Karki, Hari S.</creatorcontrib><creatorcontrib>Jupe, Florian</creatorcontrib><creatorcontrib>Witek, Agnieszka I.</creatorcontrib><creatorcontrib>Steuernagel, Burkhard</creatorcontrib><creatorcontrib>Stam, Remco</creatorcontrib><creatorcontrib>van Oosterhout, Cock</creatorcontrib><creatorcontrib>Fairhead, Sebastian</creatorcontrib><creatorcontrib>Heal, Robert</creatorcontrib><creatorcontrib>Cocker, Jonathan M.</creatorcontrib><creatorcontrib>Bhanvadia, Shivani</creatorcontrib><creatorcontrib>Barrett, William</creatorcontrib><creatorcontrib>Wu, Chih-Hang</creatorcontrib><creatorcontrib>Adachi, Hiroaki</creatorcontrib><creatorcontrib>Song, Tianqiao</creatorcontrib><creatorcontrib>Kamoun, Sophien</creatorcontrib><creatorcontrib>Vleeshouwers, Vivianne G. A. A.</creatorcontrib><creatorcontrib>Tomlinson, Laurence</creatorcontrib><creatorcontrib>Wulff, Brande B. H.</creatorcontrib><creatorcontrib>Jones, Jonathan D. G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Ecology Abstracts</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature plants</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Witek, Kamil</au><au>Lin, Xiao</au><au>Karki, Hari S.</au><au>Jupe, Florian</au><au>Witek, Agnieszka I.</au><au>Steuernagel, Burkhard</au><au>Stam, Remco</au><au>van Oosterhout, Cock</au><au>Fairhead, Sebastian</au><au>Heal, Robert</au><au>Cocker, Jonathan M.</au><au>Bhanvadia, Shivani</au><au>Barrett, William</au><au>Wu, Chih-Hang</au><au>Adachi, Hiroaki</au><au>Song, Tianqiao</au><au>Kamoun, Sophien</au><au>Vleeshouwers, Vivianne G. A. A.</au><au>Tomlinson, Laurence</au><au>Wulff, Brande B. H.</au><au>Jones, Jonathan D. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector</atitle><jtitle>Nature plants</jtitle><stitle>Nat. Plants</stitle><addtitle>Nat Plants</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>7</volume><issue>2</issue><spage>198</spage><epage>208</epage><pages>198-208</pages><eissn>2055-0278</eissn><abstract>Late blight caused by
Phytophthora infestans
greatly constrains potato production. Many
Resistance (R)
genes were cloned from wild
Solanum
species and/or introduced into potato cultivars by breeding. However, individual
R
genes have been overcome by
P. infestans
evolution; durable resistance remains elusive. We positionally cloned a new
R
gene,
Rpi-amr1
, from
Solanum americanum
, that encodes an NRC helper-dependent CC-NLR protein.
Rpi-amr1
confers resistance in potato to all 19
P. infestans
isolates tested. Using association genomics and long-read RenSeq, we defined eight additional
Rpi-amr1
alleles from different
S. americanum
and related species. Despite only ~90% identity between Rpi-amr1 proteins, all confer late blight resistance but differentially recognize
Avramr1
orthologues and paralogues. We propose that
Rpi-amr1
gene family diversity assists detection of diverse paralogues and alleles of the recognized effector, facilitating durable resistance against
P. infestans
.
The authors apply state-of-the-art genomic approaches to characterize a novel late blight resistance gene in a wild Solanaceae. This gene, when expressed in cultivated potato, confers a broad and robust resistance to many
Phytophthora infestans
isolates.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33574576</pmid><doi>10.1038/s41477-021-00854-9</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8284-7728</orcidid><orcidid>https://orcid.org/0000-0002-5653-738X</orcidid><orcidid>https://orcid.org/0000-0003-0659-5562</orcidid><orcidid>https://orcid.org/0000-0002-4953-261X</orcidid><orcidid>https://orcid.org/0000-0002-8160-4556</orcidid><orcidid>https://orcid.org/0000-0003-4044-4346</orcidid><orcidid>https://orcid.org/0000-0002-3848-0244</orcidid><orcidid>https://orcid.org/0000-0002-0290-0315</orcidid><orcidid>https://orcid.org/0000-0002-4946-6149</orcidid><orcidid>https://orcid.org/0000-0002-3444-6954</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nature plants, 2021-02, Vol.7 (2), p.198-208 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7116783 |
| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | 38 45 45/23 45/41 45/77 45/91 631/208/212 631/208/2491 631/208/711 631/449/2169 631/449/711 Alleles Biomedical and Life Sciences Chromosome Mapping Cloning Cloning, Molecular - methods Cultivars Disease resistance Disease Resistance - genetics Evolutionary genetics Gene Expression Regulation, Plant Genes Genes, Plant Genomics Introduced species Late blight Life Sciences Nlr protein Phytophthora infestans Phytophthora infestans - pathogenicity Plant breeding Plant Breeding - methods Plant Diseases - genetics Plant Immunity - genetics Plant Sciences Potatoes Proteins Solanum - genetics Solanum americanum Vegetables |
| title | A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector |
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