A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector
Late blight caused by Phytophthora infestans greatly constrains potato production. Many Resistance (R) genes were cloned from wild Solanum species and/or introduced into potato cultivars by breeding. However, individual R genes have been overcome by P. infestans evolution; durable resistance remains...
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Veröffentlicht in: | Nature plants 2021-02, Vol.7 (2), p.198-208 |
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Zusammenfassung: | Late blight caused by
Phytophthora infestans
greatly constrains potato production. Many
Resistance (R)
genes were cloned from wild
Solanum
species and/or introduced into potato cultivars by breeding. However, individual
R
genes have been overcome by
P. infestans
evolution; durable resistance remains elusive. We positionally cloned a new
R
gene,
Rpi-amr1
, from
Solanum americanum
, that encodes an NRC helper-dependent CC-NLR protein.
Rpi-amr1
confers resistance in potato to all 19
P. infestans
isolates tested. Using association genomics and long-read RenSeq, we defined eight additional
Rpi-amr1
alleles from different
S. americanum
and related species. Despite only ~90% identity between Rpi-amr1 proteins, all confer late blight resistance but differentially recognize
Avramr1
orthologues and paralogues. We propose that
Rpi-amr1
gene family diversity assists detection of diverse paralogues and alleles of the recognized effector, facilitating durable resistance against
P. infestans
.
The authors apply state-of-the-art genomic approaches to characterize a novel late blight resistance gene in a wild Solanaceae. This gene, when expressed in cultivated potato, confers a broad and robust resistance to many
Phytophthora infestans
isolates. |
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ISSN: | 2055-0278 |
DOI: | 10.1038/s41477-021-00854-9 |