Genome-wide association study identifies 48 common genetic variants associated with handedness

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature human behaviour 2021-01, Vol.5 (1), p.59-70
Hauptverfasser:	Cuellar-Partida, Gabriel, Tung, Joyce Y., Eriksson, Nicholas, Albrecht, Eva, Andreassen, Ole A., Boomsma, Dorret I., Boyd, Heather A., Breteler, Monique M. B., Campbell, Harry, Chasman, Daniel I., Cherkas, Lynn F., Davies, Gail, de Geus, Eco J. C., Deloukas, Panos, Duffy, David L., Eriksson, Johan G., Esko, Tõnu, Feenstra, Bjarke, Geller, Frank, Gieger, Christian, Giegling, Ina, Gordon, Scott D., Han, Jiali, Hansen, Thomas F., Hartmann, Annette M., Hayward, Caroline, Heikkilä, Kauko, Hicks, Andrew A., Hirschhorn, Joel N., Hottenga, Jouke-Jan, Huffman, Jennifer E., Hwang, Liang-Dar, Ikram, M. Arfan, Kaprio, Jaakko, Kemp, John P., Khaw, Kay-Tee, Klopp, Norman, Kutalik, Zoltan, Lahti, Jari, Li, Xin, Loos, Ruth J. F., Magnusson, Sigurdur H., Mangino, Massimo, Marques-Vidal, Pedro, Martin, Nicholas G., McArdle, Wendy L., McCarthy, Mark I., Medina-Gomez, Carolina, Melbye, Mads, Metspalu, Andres, Milani, Lili, Mooser, Vincent, Nelis, Mari, Nyholt, Dale R., O’Connell, Kevin S., Ophoff, Roel A., Palmer, Cameron, Palotie, Aarno, Palviainen, Teemu, Paternoster, Lavinia, Peltonen, Leena, Penninx, Brenda W. J. H., Pramstaller, Peter P., Prokopenko, Inga, Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rujescu, Dan, Smit, Johannes H., Smith, George Davey, Smoller, Jordan W., Spector, Tim D., Pourcain, Beate St, Starr, John M., Stefánsson, Hreinn, Steinberg, Stacy, Teder-Laving, Maris, Uitterlinden, André G., van Duijn, Cornelia M., van Rooij, Frank J. A., Vink, Jaqueline M., Vollenweider, Peter, Vuoksimaa, Eero, Wareham, Nicholas J., Waterworth, Dawn, Werge, Thomas, Wichmann, H.-Erich, Widen, Elisabeth, Willemsen, Gonneke, Wright, Alan F., Wright, Margaret J., Xu, Mousheng, Zhao, Jing Hua, Kraft, Peter, Hinds, David A., Lindgren, Cecilia M., Mägi, Reedik, Neale, Benjamin M., Evans, David M., Medland, Sarah E.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/43 631/208/205 631/378 Adult Aged Associations Behavioral Sciences Biomedical and Life Sciences Bipolar disorder Etiology Experimental Psychology Female Functional Laterality - genetics Gene Frequency - genetics Genetic Loci - genetics Genetic Variation - genetics Genome-Wide Association Study Genomes Genomics Handedness Humans Life Sciences Linkage Disequilibrium Male Mental disorders Microeconomics Middle Aged Morphology Neurodevelopmental disorders Neurosciences Personality and Social Psychology Polymorphism, Single Nucleotide - genetics Quantitative Trait, Heritable Schizophrenia Sex Factors Systematic review Variants
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness ( N = 1,766,671). We found 41 loci associated ( P
ISSN:	2397-3374 2397-3374
DOI:	10.1038/s41562-020-00956-y