Chimeric calicivirus-like particles elicit specific immune responses in pigs

Highlights ► Chimeric RHDV-VLPs were able to mature porcine and human dendritic cells in vitro . ► Chimeric RHDV-VLPs stimulate specific humoral and cellular responses in pigs. ► Pigs immunised with chimeric RHDV-VLPs + adjuvant showed the best responses. ► Intramuscular route was the most effective...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2012-03, Vol.30 (14), p.2427-2439
Hauptverfasser:	Crisci, E, Fraile, L, Moreno, N, Blanco, E, Cabezón, R, Costa, C, Mussá, T, Baratelli, M, Martinez-Orellana, P, Ganges, L, Martínez, J, Bárcena, J, Montoya, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - metabolism Adjuvants Allergy and Immunology Amino Acid Sequence Animals antibodies Antibodies, Viral - immunology Antibody Specificity Bone marrow Cell number chimerism Cytokines - metabolism Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Enzyme-linked immunosorbent assay Epitopes Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - immunology FMDV Foot-and-mouth disease Foot-and-mouth disease virus gamma -Interferon Hemorrhagic Disease Virus, Rabbit - immunology Hogs Humans Immune response Immune system Immunity Immunity, Cellular Immunization Immunogenicity Immunoglobulin A Immunoglobulin G Lymphocytes Lymphocytes T Male Medical research mice Molecular Sequence Data Pigs Proteins Rabbit hemorrhagic disease virus RHDV-VLPs Studies Swine Swine - immunology T-lymphocytes Vaccine vector Vaccines Vaccines, Virus-Like Particle - immunology Viral Proteins - chemistry Viral Proteins - immunology Virus-like particles
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► Chimeric RHDV-VLPs were able to mature porcine and human dendritic cells in vitro . ► Chimeric RHDV-VLPs stimulate specific humoral and cellular responses in pigs. ► Pigs immunised with chimeric RHDV-VLPs + adjuvant showed the best responses. ► Intramuscular route was the most effective route of immunisation. ► The responses were dose-independent in the tested range.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.01.069