Fatal multiorgan failure due to yellow fever vaccine-associated viscerotropic disease

Abstract Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a rare complication of yellow fever (YF) vaccination. A previously healthy 22-year-old female died following YF vaccination despite aggressive measures. Serial viral load titers, cytokine levels and host genetic factors were...

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Veröffentlicht in:	Vaccine 2007-12, Vol.25 (50), p.8480-8485
Hauptverfasser:	Belsher, Jon L, Gay, Peter, Brinton, Margo, DellaValla, Joseph, Ridenour, Robert, Lanciotti, Robert, Perelygin, Andrey, Zaki, Sherif, Paddock, Christopher, Querec, Troy, Zhu, Tuofu, Pulendran, Bali, Eidex, Rachel B, Hayes, Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Antibiotics Applied microbiology Arboviroses Bacterial infections Biological and medical sciences Blood pressure Cytokines Fatal Outcome Fatalities Female Fluids Fundamental and applied biological sciences. Psychology Genetic factors Hepatitis Human viral diseases Humans Immunization Infectious diseases Medical laboratories Medical sciences Microbiology Multiple Organ Failure - etiology Pain Proteins Tropical viral diseases Ultrasonic imaging Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vector-borne diseases Ventilation Viral diseases Yellow fever Yellow Fever - prevention & control Yellow fever vaccination Yellow Fever Vaccine - administration & dosage Yellow Fever Vaccine - adverse effects Yellow fever vaccine-associated viscerotropic disease
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Zusammenfassung:	Abstract Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a rare complication of yellow fever (YF) vaccination. A previously healthy 22-year-old female died following YF vaccination despite aggressive measures. Serial viral load titers, cytokine levels and host genetic factors were evaluated in an attempt to understand this unusual and lethal outcome. The patient's high-titer vaccine viremia and possibly related minor genetic anomalies provide clues to exploring the etiology of YEL-AVD.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2007.08.061