A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

Highlights • Recombinant DNA technologies are leading the rapid expansion of bispecific antibody formats. • The therapeutic potential of bispecific antibodies is being realized through creative design. • Bispecific antibodies are potentially underutilized reagents for diagnostics.

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Bibliographische Detailangaben
Veröffentlicht in:	Trends in biotechnology (Regular ed.) 2013-11, Vol.31 (11), p.621-632
Hauptverfasser:	Byrne, Hannah, Conroy, Paul J, Whisstock, James C, O’Kennedy, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	antibodies Antibodies, Bispecific - genetics Antibodies, Bispecific - isolation & purification Antibodies, Bispecific - therapeutic use Antibodies, Monoclonal - genetics Antibodies, Monoclonal - isolation & purification Antibodies, Monoclonal - therapeutic use Apoptosis Binding sites Biological and medical sciences Biotechnology Biotechnology - methods Biotechnology - trends Cytotoxicity Deoxyribonucleic acid DNA Fundamental and applied biological sciences. Psychology genes Immune system Internal Medicine Melanoma Molecular weight Point-of-Care Systems - trends Protein Engineering - methods Protein Engineering - trends Proteins recombinant antibodies Recombinant Proteins - genetics Recombinant Proteins - isolation & purification Recombinant Proteins - therapeutic use Regulatory approval Review Single-Chain Antibodies - genetics Single-Chain Antibodies - isolation & purification Single-Chain Antibodies - therapeutic use T cell receptors Technological change Technology, Pharmaceutical - methods Technology, Pharmaceutical - trends therapeutics
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Beschreibung
Zusammenfassung:	Highlights • Recombinant DNA technologies are leading the rapid expansion of bispecific antibody formats. • The therapeutic potential of bispecific antibodies is being realized through creative design. • Bispecific antibodies are potentially underutilized reagents for diagnostics.
ISSN:	0167-7799 1879-3096
DOI:	10.1016/j.tibtech.2013.08.007