An evolving arsenal: viral RNA detection by RIG-I-like receptors

Highlights • RIG-I-like receptors (RLRs) have similar architectures but unique recognition domains. • Structural diversity among RLRs provides multiple strategies for detecting viral RNA. • Viruses evade detection by exploiting RLR specificity for RNA determinants. • RLR architecture has evolved in...

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Veröffentlicht in:	Current opinion in microbiology 2014-08, Vol.20, p.76-81
Hauptverfasser:	Fitzgerald, Megan E, Rawling, David C, Vela, Adriana, Pyle, Anna Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DEAD-box RNA Helicases - immunology DEAD-box RNA Helicases - metabolism Host-Pathogen Interactions Humans Immune Evasion Pathology Receptors, Immunologic - immunology Receptors, Immunologic - metabolism RNA, Double-Stranded - immunology RNA, Double-Stranded - metabolism RNA, Viral - immunology RNA, Viral - metabolism
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Beschreibung
Zusammenfassung:	Highlights • RIG-I-like receptors (RLRs) have similar architectures but unique recognition domains. • Structural diversity among RLRs provides multiple strategies for detecting viral RNA. • Viruses evade detection by exploiting RLR specificity for RNA determinants. • RLR architecture has evolved in response to variations in viral RNA diversity.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2014.05.004