Coxiella burnetii: international pathogen of mystery

Coxiella burnetii: international pathogen of mystery

Coxiella burnetii is an intracellular bacterium that causes acute and chronic Q fever. This unique pathogen has been historically challenging to study due to obstacles in genetically manipulating the organism and the inability of small animal models to fully mimic human Q fever. Here, we review the...

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Veröffentlicht in:Microbes and infection 2020-04, Vol.22 (3), p.100-110
Hauptverfasser: Dragan, Amanda L., Voth, Daniel E.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Coxiella burnetii
Coxiella burnetii - pathogenicity
Cytoplasm - microbiology
Disease Models, Animal
Global Health
Humans
Intracellular
Macrophage
Macrophages - microbiology
Q fever
Q Fever - microbiology
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Zusammenfassung:Coxiella burnetii is an intracellular bacterium that causes acute and chronic Q fever. This unique pathogen has been historically challenging to study due to obstacles in genetically manipulating the organism and the inability of small animal models to fully mimic human Q fever. Here, we review the current state of C. burnetii research, highlighting new approaches that allow the mechanistic study of infection in disease relevant settings.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2019.09.001