Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020

The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a s...

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Veröffentlicht in:	Euro surveillance : bulletin européen sur les maladies transmissibles 2020-03, Vol.25 (11)
Hauptverfasser:	Haveri, Anu, Smura, Teemu, Kuivanen, Suvi, Österlund, Pamela, Hepojoki, Jussi, Ikonen, Niina, Pitkäpaasi, Marjaana, Blomqvist, Soile, Rönkkö, Esa, Kantele, Anu, Strandin, Tomas, Kallio-Kokko, Hannimari, Mannonen, Laura, Lappalainen, Maija, Broas, Markku, Jiang, Miao, Siira, Lotta, Salminen, Mika, Puumalainen, Taneli, Sane, Jussi, Melin, Merit, Vapalahti, Olli, Savolainen-Kopra, Carita
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Viral - blood Asymptomatic Infections Betacoronavirus China Clinical Laboratory Techniques Contact Tracing Coronavirus - genetics Coronavirus - immunology Coronavirus - isolation & purification Coronavirus Infections - diagnosis Coronavirus Infections - transmission Coronavirus Infections - virology COVID-19 COVID-19 Testing Female Finland Fluorescent Antibody Technique Humans Immunoglobulin A - blood Immunoglobulin G - blood Immunoglobulin M - blood Neutralization Tests Pandemics Pneumonia, Viral - diagnosis Pneumonia, Viral - transmission Pneumonia, Viral - virology Rapid Communication SARS Virus - immunology SARS Virus - pathogenicity SARS-CoV-2 Severe Acute Respiratory Syndrome - etiology Severe Acute Respiratory Syndrome - immunology Severe Acute Respiratory Syndrome - virology Travel Viral Envelope Proteins
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Zusammenfassung:	The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.
ISSN:	1560-7917 1025-496X 1560-7917
DOI:	10.2807/1560-7917.es.2020.25.11.2000266