Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine

Lung remains the least-utilized solid organ for transplantation. Efforts to recover donor lungs with reversible injuries using ex vivo perfusion systems are limited to 400 mm Hg; compliance >20 mL/cm H2O), and recipient swine were hemodynamically stable (lactate

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2020-04, Vol.159 (4), p.1640-1653.e18
Hauptverfasser:	Hozain, Ahmed E., Tipograf, Yuliya, Pinezich, Meghan R., Cunningham, Katherine M., Donocoff, Rachel, Queen, Dawn, Fung, Kenmond, Marboe, Charles C., Guenthart, Brandon A., O'Neill, John D., Vunjak-Novakovic, Gordana, Bacchetta, Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lung injury airway lavage alveolar recruitment Animals bronchoalveolar lavage fluid chimerism cross-circulation ex vivo lung perfusion Extracorporeal Circulation - methods extracorporeal membrane oxygenation infrared thermography lung bioengineering lung transplantation Lung Transplantation - methods medical thermography Models, Animal normothermic organ perfusion Organ Preservation - methods organ shortage regenerative medicine Swine swine model Time Factors tissue engineering transplantation whole organ bioreactor
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Beschreibung
Zusammenfassung:	Lung remains the least-utilized solid organ for transplantation. Efforts to recover donor lungs with reversible injuries using ex vivo perfusion systems are limited to 400 mm Hg; compliance >20 mL/cm H2O), and recipient swine were hemodynamically stable (lactate
ISSN:	0022-5223 1097-685X
DOI:	10.1016/j.jtcvs.2019.09.121