Increased Circulating Angiopoietin-Like Protein 8 Levels Are Associated with Thoracic Aortic Dissection and Higher Inflammatory Conditions

Purpose Thoracic aortic dissection (TAD) is characterized by an inflammatory response. Angiopoietin-like protein 8 (ANGPTL8) is a hormone involved in the regulation of lipid metabolism and inflammation. However, the relationship between ANGPTL8 and TAD remains unknown. Methods This case-control stud...

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Veröffentlicht in:	Cardiovascular drugs and therapy 2020-02, Vol.34 (1), p.65-77
Hauptverfasser:	Yang, Yunyun, Jiao, Xiaolu, Li, Linyi, Hu, Chaowei, Zhang, Xiaoping, Pan, Lili, Yu, Huahui, Li, Juan, Chen, Dong, Du, Jie, Qin, Yanwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aneurysm, Dissecting - blood Aneurysm, Dissecting - diagnostic imaging Angiopoietin Angiopoietin-like Proteins - blood Angiopoietin-like Proteins - genetics Angiotensin Angiotensin II Animals Aorta Aortic Aneurysm, Thoracic - blood Aortic Aneurysm, Thoracic - diagnostic imaging Aortic dissection Apoptosis Biomarkers - blood C-reactive protein C-Reactive Protein - analysis Cardiology Case-Control Studies Computed tomography Confidence intervals Cytokines - metabolism Diameters Dimers Dissection Enzyme-linked immunosorbent assay Female Fibrin Fibrinogen Degradation Products - analysis Humans Inflammation Inflammation - blood Inflammation - diagnosis Inflammation Mediators - blood Inflammatory response Lipid metabolism Lipids Macrophages Macrophages - metabolism Male Medicine Medicine & Public Health Mice Middle Aged Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Muscles Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Original Original Article Peptide Hormones - blood Peptide Hormones - genetics Proteins RAW 264.7 Cells Regression analysis Risk analysis Risk factors Sensitivity siRNA Smooth muscle Statistical analysis Thorax Up-Regulation
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Zusammenfassung:	Purpose Thoracic aortic dissection (TAD) is characterized by an inflammatory response. Angiopoietin-like protein 8 (ANGPTL8) is a hormone involved in the regulation of lipid metabolism and inflammation. However, the relationship between ANGPTL8 and TAD remains unknown. Methods This case-control study included 78 TAD patients and 72 controls. The aortic diameter was evaluated by computed tomography and used to assess TAD severity. Circulating ANGPTL8 levels were measured by enzyme-linked immunosorbent assay. Associations of ANGPTL8 with TAD were determined by multivariate logistic regression. Results Serum ANGPTL8 levels were significantly higher in TAD patients compared with controls (562.50 ± 20.84 vs. 419.70 ± 22.65 pg/mL, respectively; P
ISSN:	0920-3206 1573-7241
DOI:	10.1007/s10557-019-06924-7