Roles of Remote and Contact Forces in Epithelial Cell Structure Formation
Cancer cells collectively form a large-scale structure for their growth. In this article, we report that HeLa cells, epithelial-like human cervical cancer cells, aggressively migrate on Matrigel and form a large-scale structure in a cell-density-dependent manner. To explain the experimental results,...
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Veröffentlicht in: | Biophysical journal 2020-03, Vol.118 (6), p.1466-1478 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Cancer cells collectively form a large-scale structure for their growth. In this article, we report that HeLa cells, epithelial-like human cervical cancer cells, aggressively migrate on Matrigel and form a large-scale structure in a cell-density-dependent manner. To explain the experimental results, we develop a simple model in which cells interact and migrate using the two fundamentally different types of force, remote and contact forces, and show how cells form a large-scale structure. We demonstrate that the simple model reproduces experimental observations, suggesting that the remote and contact forces considered in this work play a major role in large-scale structure formation of HeLa cells. This article provides important evidence that cancer cells form a large-scale structure and develops an understanding into the poorly understood mechanisms of their structure formation. |
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ISSN: | 0006-3495 1542-0086 |
DOI: | 10.1016/j.bpj.2020.01.037 |