Synthesis and antiviral activity of 18α-glycyrrhizic acid and its esters

New esters (sulfate, nicotinates, and 4-methoxycinnamate) of 18α-glycyrrhizic acid (18α-GA) were synthesized; these were D/E-trans-isomers of natural 18β-GA (GA), which is the major triterpene glycoside in the roots of Spanish licorice and Urals licorice (Glycyrrhiza glabra L. and Gl. uralensis Fish...

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Veröffentlicht in:	Pharmaceutical chemistry journal 2010, Vol.44 (6), p.299-302
Hauptverfasser:	Baltina, L. A. Jr, Stolyarova, O. V, Baltina, L. A, Kondratenko, R. M, Plyasunova, O. A, Pokrovskii, A. G
Format:	Artikel
Sprache:	eng
Schlagworte:	18α-glycyrrhizic acid anti-HIV activity esters Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	New esters (sulfate, nicotinates, and 4-methoxycinnamate) of 18α-glycyrrhizic acid (18α-GA) were synthesized; these were D/E-trans-isomers of natural 18β-GA (GA), which is the major triterpene glycoside in the roots of Spanish licorice and Urals licorice (Glycyrrhiza glabra L. and Gl. uralensis Fisher). Changes in the stereochemistry of the GA aglycone led to significant decreases in its anti-HIV-1 activity.
ISSN:	0091-150X 1573-9031
DOI:	10.1007/s11094-010-0454-1