Effect of New Antiviral Agent Camphecin on Behavior of Mice

We studied the effect of camphecin (1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene-aminoethanol) on mouse behavior in the open-field test. Camphecin possesses antiviral activity and inhibits viral replication, but its influence on the nervous system is poorly studied. Single camphecin injection produ...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2017-01, Vol.162 (3), p.346-348
Hauptverfasser:	Babina, A. V., Lavrinenko, V. A., Yarovaya, O. I., Salakhutdinov, N. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral activity Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Anxiety Behavior, Animal - drug effects Behavior, Animal - physiology Biomedical and Life Sciences Biomedicine Bridged Bicyclo Compounds - chemical synthesis Bridged Bicyclo Compounds - pharmacology Cell Biology Emotions Ethanolamines - chemical synthesis Ethanolamines - pharmacology Exploratory behavior Exploratory Behavior - drug effects Exploratory Behavior - physiology Female Health aspects Internal Medicine Laboratory Medicine Male Maze Learning - drug effects Maze Learning - physiology Mice Mice, Inbred AKR Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred CBA Mice, Inbred DBA Motor Activity - drug effects Motor Activity - physiology Motor task performance Nervous system Open-field behavior Pathology Pharmacology and Toxicology Virus diseases Virus replication
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Beschreibung
Zusammenfassung:	We studied the effect of camphecin (1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene-aminoethanol) on mouse behavior in the open-field test. Camphecin possesses antiviral activity and inhibits viral replication, but its influence on the nervous system is poorly studied. Single camphecin injection produced no significant changes in behavioral patterns. Chronic camphecin administration (5 times over 2 weeks) to mice of different strains had no significant influence on open field behavior (motor, exploratory activity, anxiety, emotional state and vegetative functions). The findings are discussed in the context of neutral influence of camphecin on animal behavior.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-017-3612-6