Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes

Most replicated genetic determinants for type 1 diabetes are common (minor allele frequency [MAF] >5%). We aimed to identify novel rare or low-frequency (MAF

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Bibliographische Detailangaben
Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2020-04, Vol.69 (4), p.784-795
Hauptverfasser:	Forgetta, Vincenzo, Manousaki, Despoina, Istomine, Roman, Ross, Stephanie, Tessier, Marie-Catherine, Marchand, Luc, Li, Min, Qu, Hui-Qi, Bradfield, Jonathan P, Grant, Struan F A, Hakonarson, Hakon, Paterson, Andrew D, Piccirillo, Ciriaco, Polychronakos, Constantin, Richards, J Brent
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - genetics Effector cells Gene Frequency Genetic diversity Genetic Predisposition to Disease Genetics/Genomes/Proteomics/Metabolomics Genome-Wide Association Study Genomes Genotype Humans Interleukin 2 Lymphocytes T Major histocompatibility complex Polymorphism, Single Nucleotide Protein-tyrosine-phosphatase Single-nucleotide polymorphism
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Beschreibung
Zusammenfassung:	Most replicated genetic determinants for type 1 diabetes are common (minor allele frequency [MAF] >5%). We aimed to identify novel rare or low-frequency (MAF
ISSN:	0012-1797 1939-327X
DOI:	10.2337/db19-0831