Plasma Glycated CD59 Predicts Early Gestational Diabetes and Large for Gestational Age Newborns

Abstract Context Gestational diabetes mellitus (GDM) diagnosed in early pregnancy is a health care challenge because it increases the risk of adverse outcomes. Plasma-glycated CD59 (pGCD59) is an emerging biomarker for diabetes and GDM. The aim of this study was to assess the performance of pGCD59 a...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2020-04, Vol.105 (4), p.e1033-e1040
Hauptverfasser:	Ma, DongDong, Luque-Fernandez, Miguel Angel, Bogdanet, Delia, Desoye, Gernot, Dunne, Fidelma, Halperin, Jose A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers Biomarkers - blood Blood Glucose - analysis Blood levels Body mass index CD59 antigen CD59 Antigens - blood Clinical s Diabetes mellitus Diabetes, Gestational - blood Diabetes, Gestational - diagnosis Diabetes, Gestational - epidemiology Female Fetal Macrosomia - blood Fetal Macrosomia - diagnosis Fetal Macrosomia - epidemiology Follow-Up Studies Gestational Age Gestational diabetes Glucose tolerance Glycosylation Humans Infant, Newborn Infant, Newborn, Diseases - blood Infant, Newborn, Diseases - diagnosis Infant, Newborn, Diseases - epidemiology Neonates Pregnancy Pregnancy Complications - blood Pregnancy Complications - diagnosis Pregnancy Complications - epidemiology Prognosis Risk assessment Risk Factors Vitamin D Young Adult
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Zusammenfassung:	Abstract Context Gestational diabetes mellitus (GDM) diagnosed in early pregnancy is a health care challenge because it increases the risk of adverse outcomes. Plasma-glycated CD59 (pGCD59) is an emerging biomarker for diabetes and GDM. The aim of this study was to assess the performance of pGCD59 as a biomarker of early GDM and its association with delivering a large for gestational age (LGA) infant. Objectives To assess the performance of pGCD59 to identify women with GDM in early pregnancy (GDM 29) undergoing a 75-g, 2-hour oral glucose tolerance test (OGTT) at
ISSN:	0021-972X 1945-7197
DOI:	10.1210/clinem/dgaa087