Degradation Potential of the Nonylphenol Monooxygenase of Sphingomonas sp. NP5 for Bisphenols and Their Structural Analogs

The nonylphenol-degrading bacterium sp. strain NP5 has a very unique monooxygenase that can attack a wide range of 4-alkylphenols with a branched side chain. Due to the structural similarity, it can also attack bisphenolic compounds, which are very important materials for the synthesis of plastics a...

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Veröffentlicht in:Microorganisms (Basel) 2020-02, Vol.8 (2), p.284
Hauptverfasser: Takeo, Masahiro, Akizuki, Junichi, Kawasaki, Aika, Negoro, Seiji
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Sprache:eng
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Zusammenfassung:The nonylphenol-degrading bacterium sp. strain NP5 has a very unique monooxygenase that can attack a wide range of 4-alkylphenols with a branched side chain. Due to the structural similarity, it can also attack bisphenolic compounds, which are very important materials for the synthesis of plastics and resins, but many of them are known to or suspected to have endocrine disrupting effects to fish and animals. In this study, to clarify the substrate specificity of the enzyme (NmoA) for bisphenolic compounds, degradation tests using the cell suspension of harboring the nonylphenol monooxygenase gene ( ) were conducted. The cell suspension degraded several bisphenols including bisphenol F, bisphenol S, 4,4'-dihydroxybenzophenone, 4,4'-dihydroxydiphenylether, and 4,4'-thiodiphenol, indicating that this monooxygenase has a broad substrate specificity for compounds with a bisphenolic structure.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms8020284