Midline Glioma in Adults: Clinicopathological, Genetic, and Epigenetic Analysis

The histone H3K27M-mutant diffuse midline glioma is often seen in children and has a very poor prognosis regardless of its histological grade. Although it can occur in adults, few studies on adult cases have been reported. We examined adult midline glioma cases for their histological grade, presence...

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Veröffentlicht in:	Neurologia medico-chirurgica 2020, Vol.60(3), pp.136-146
Hauptverfasser:	ENOMOTO, Toshiyuki, AOKI, Mikiko, HAMASAKI, Makoto, ABE, Hiroshi, NONAKA, Masani, INOUE, Tooru, NABESHIMA, Kazuki
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Methylthioadenosine phosphorylase Adolescent Adult Age Factors Aged Aged, 80 and over Brain Neoplasms - genetics Brain Neoplasms - mortality Brain Neoplasms - pathology Children diffuse midline glioma Enhancer of Zeste Homolog 2 Protein - genetics Epigenesis, Genetic EZH2 Female Genes, p16 Genetic analysis Glioma Glioma - genetics Glioma - mortality Glioma - pathology H3K27M H3K27me3 Humans Jumonji Domain-Containing Histone Demethylases - genetics Male Malignancy Medical prognosis Middle Aged Mutants Mutation Original Phosphorylase Prognosis Purine-Nucleoside Phosphorylase - genetics Survival Rate Young Adult Young adults
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Zusammenfassung:	The histone H3K27M-mutant diffuse midline glioma is often seen in children and has a very poor prognosis regardless of its histological grade. Although it can occur in adults, few studies on adult cases have been reported. We examined adult midline glioma cases for their histological grade, presence of H3K27M mutation, and expression of related factors—enhancer of zeste homolog 2 (EZH2), H3K27me3, p16, and methylthioadenosine phosphorylase. These tumor characteristics were also evaluated for their prognostic value in adult midline glioma. High histological grade, H3K27M-mutant, high EZH2 expression, and high H3K27me3 expression was detected in 12/23 (53%), 11/23 (48%), 9/23 (39%), and 12/23 (52%) cases, respectively. Histological grade and prognosis were significantly correlated (P
ISSN:	0470-8105 1349-8029
DOI:	10.2176/nmc.oa.2019-0168