Incidence of frontotemporal disorders in Olmsted County: A population-based study
Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort. Using a records-linkage system, we identified all patients with a...
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| Veröffentlicht in: | Alzheimer's & dementia 2020-03, Vol.16 (3), p.482-490 |
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| creator | Turcano, Pierpaolo Stang, Cole D. Mielke, Michelle M. Martin, Peter R. Upadhyaya, Sudhindra G. Josephs, Keith A. Boeve, Bradley F. Knopman, David S. Petersen, Ronald C. Savica, Rodolfo |
| description | Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort.
Using a records-linkage system, we identified all patients with a diagnostic code for dementia in Olmsted County, MN, 1995–2010, and confirmed the diagnosis of FTD. A behavioral neurologist verified the clinical diagnosis and determined phenotypes.
We identified 35 FTD cases. Overall, the incidence of FTDs was 4.3/100,000/year (95% CI: 2.9, 5.7). Incidence was higher in men (6.3/100,000, 95% CI 3.6, 9.0) than women (2.9/100,000; 95% CI: 1.3, 4.5); we observed an increased trend over time (B = 0.83, 95% CI: 0.54, 1.11, P |
| doi_str_mv | 10.1016/j.jalz.2019.08.199 |
| format | Article |
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Using a records-linkage system, we identified all patients with a diagnostic code for dementia in Olmsted County, MN, 1995–2010, and confirmed the diagnosis of FTD. A behavioral neurologist verified the clinical diagnosis and determined phenotypes.
We identified 35 FTD cases. Overall, the incidence of FTDs was 4.3/100,000/year (95% CI: 2.9, 5.7). Incidence was higher in men (6.3/100,000, 95% CI 3.6, 9.0) than women (2.9/100,000; 95% CI: 1.3, 4.5); we observed an increased trend over time (B = 0.83, 95% CI: 0.54, 1.11, P < .001). At autopsy, clinical diagnosis was confirmed in eight (72.7%) cases.
We observed an increased incidence and trends of FTDs over time. This may reflect a better recognition by clinicians and improvement of clinical criteria and diagnostic tools.</description><identifier>ISSN: 1552-5260</identifier><identifier>ISSN: 1552-5279</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1016/j.jalz.2019.08.199</identifier><identifier>PMID: 31784373</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Behavioral variant frontotemporal dementia ; Cohort Studies ; Female ; Frontotemporal Dementia - diagnosis ; Frontotemporal Dementia - epidemiology ; Frontotemporal-dementia disorders (FTDs) ; Humans ; Incidence ; Male ; Middle Aged ; Minnesota ; Neurodegenerative dementia ; Population-based cohort ; Sex Factors</subject><ispartof>Alzheimer's & dementia, 2020-03, Vol.16 (3), p.482-490</ispartof><rights>2019 the Alzheimer's Association</rights><rights>2019 the Alzheimer's Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5049-4161e94451b02823891246500ae7b573b63d80c3c202b7a64d8601b536c743263</citedby><cites>FETCH-LOGICAL-c5049-4161e94451b02823891246500ae7b573b63d80c3c202b7a64d8601b536c743263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.jalz.2019.08.199$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.jalz.2019.08.199$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31784373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turcano, Pierpaolo</creatorcontrib><creatorcontrib>Stang, Cole D.</creatorcontrib><creatorcontrib>Mielke, Michelle M.</creatorcontrib><creatorcontrib>Martin, Peter R.</creatorcontrib><creatorcontrib>Upadhyaya, Sudhindra G.</creatorcontrib><creatorcontrib>Josephs, Keith A.</creatorcontrib><creatorcontrib>Boeve, Bradley F.</creatorcontrib><creatorcontrib>Knopman, David S.</creatorcontrib><creatorcontrib>Petersen, Ronald C.</creatorcontrib><creatorcontrib>Savica, Rodolfo</creatorcontrib><title>Incidence of frontotemporal disorders in Olmsted County: A population-based study</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort.
Using a records-linkage system, we identified all patients with a diagnostic code for dementia in Olmsted County, MN, 1995–2010, and confirmed the diagnosis of FTD. A behavioral neurologist verified the clinical diagnosis and determined phenotypes.
We identified 35 FTD cases. Overall, the incidence of FTDs was 4.3/100,000/year (95% CI: 2.9, 5.7). Incidence was higher in men (6.3/100,000, 95% CI 3.6, 9.0) than women (2.9/100,000; 95% CI: 1.3, 4.5); we observed an increased trend over time (B = 0.83, 95% CI: 0.54, 1.11, P < .001). At autopsy, clinical diagnosis was confirmed in eight (72.7%) cases.
We observed an increased incidence and trends of FTDs over time. This may reflect a better recognition by clinicians and improvement of clinical criteria and diagnostic tools.</description><subject>Aged</subject><subject>Behavioral variant frontotemporal dementia</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Frontotemporal Dementia - diagnosis</subject><subject>Frontotemporal Dementia - epidemiology</subject><subject>Frontotemporal-dementia disorders (FTDs)</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Minnesota</subject><subject>Neurodegenerative dementia</subject><subject>Population-based cohort</subject><subject>Sex Factors</subject><issn>1552-5260</issn><issn>1552-5279</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuLFDEUhYMozjj6B1xILd1UefNOiQhN42OgYRB04yakkrSmqUrKpGqG9tdbRY-NbsRVAveccw_3Q-g5hgYDFq8OzcH0PxsCuG1ANbhtH6BLzDmpOZHtw_NfwAV6UsoBgIHC_DG6oFgqRiW9RJ-uow3OR-urtK_2OcUpTX4YUzZ95UJJ2flcqhCrm34ok3fVNs1xOr6uNtWYxrk3U0ix7kxZRmWa3fEperQ3ffHP7t8r9OX9u8_bj_Xu5sP1drOrLQfW1gwL7FvGOO6AKEJViwkTHMB42XFJO0GdAkstAdJJI5hTAnDHqbCSUSLoFXp7yh3nbvDO-jgtnfWYw2DyUScT9N-TGL7rb-lWSxBSMLwEvLwPyOnH7Mukh1Cs73sTfZqLJpQAVUD4uoucpDanUrLfn9dg0CsLfdArC72y0KD0wmIxvfiz4Nny-_iLQJ0Ed6H3x_-I1JvdV7yUWrPfnKx-ufBt8FkXG1aKLmRvJ-1S-Fe1X5UprEc</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Turcano, Pierpaolo</creator><creator>Stang, Cole D.</creator><creator>Mielke, Michelle M.</creator><creator>Martin, Peter R.</creator><creator>Upadhyaya, Sudhindra G.</creator><creator>Josephs, Keith A.</creator><creator>Boeve, Bradley F.</creator><creator>Knopman, David S.</creator><creator>Petersen, Ronald C.</creator><creator>Savica, Rodolfo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202003</creationdate><title>Incidence of frontotemporal disorders in Olmsted County: A population-based study</title><author>Turcano, Pierpaolo ; Stang, Cole D. ; Mielke, Michelle M. ; Martin, Peter R. ; Upadhyaya, Sudhindra G. ; Josephs, Keith A. ; Boeve, Bradley F. ; Knopman, David S. ; Petersen, Ronald C. ; Savica, Rodolfo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5049-4161e94451b02823891246500ae7b573b63d80c3c202b7a64d8601b536c743263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Behavioral variant frontotemporal dementia</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Frontotemporal Dementia - diagnosis</topic><topic>Frontotemporal Dementia - epidemiology</topic><topic>Frontotemporal-dementia disorders (FTDs)</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Minnesota</topic><topic>Neurodegenerative dementia</topic><topic>Population-based cohort</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turcano, Pierpaolo</creatorcontrib><creatorcontrib>Stang, Cole D.</creatorcontrib><creatorcontrib>Mielke, Michelle M.</creatorcontrib><creatorcontrib>Martin, Peter R.</creatorcontrib><creatorcontrib>Upadhyaya, Sudhindra G.</creatorcontrib><creatorcontrib>Josephs, Keith A.</creatorcontrib><creatorcontrib>Boeve, Bradley F.</creatorcontrib><creatorcontrib>Knopman, David S.</creatorcontrib><creatorcontrib>Petersen, Ronald C.</creatorcontrib><creatorcontrib>Savica, Rodolfo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turcano, Pierpaolo</au><au>Stang, Cole D.</au><au>Mielke, Michelle M.</au><au>Martin, Peter R.</au><au>Upadhyaya, Sudhindra G.</au><au>Josephs, Keith A.</au><au>Boeve, Bradley F.</au><au>Knopman, David S.</au><au>Petersen, Ronald C.</au><au>Savica, Rodolfo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of frontotemporal disorders in Olmsted County: A population-based study</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2020-03</date><risdate>2020</risdate><volume>16</volume><issue>3</issue><spage>482</spage><epage>490</epage><pages>482-490</pages><issn>1552-5260</issn><issn>1552-5279</issn><eissn>1552-5279</eissn><abstract>Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort.
Using a records-linkage system, we identified all patients with a diagnostic code for dementia in Olmsted County, MN, 1995–2010, and confirmed the diagnosis of FTD. A behavioral neurologist verified the clinical diagnosis and determined phenotypes.
We identified 35 FTD cases. Overall, the incidence of FTDs was 4.3/100,000/year (95% CI: 2.9, 5.7). Incidence was higher in men (6.3/100,000, 95% CI 3.6, 9.0) than women (2.9/100,000; 95% CI: 1.3, 4.5); we observed an increased trend over time (B = 0.83, 95% CI: 0.54, 1.11, P < .001). At autopsy, clinical diagnosis was confirmed in eight (72.7%) cases.
We observed an increased incidence and trends of FTDs over time. This may reflect a better recognition by clinicians and improvement of clinical criteria and diagnostic tools.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31784373</pmid><doi>10.1016/j.jalz.2019.08.199</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Behavioral variant frontotemporal dementia Cohort Studies Female Frontotemporal Dementia - diagnosis Frontotemporal Dementia - epidemiology Frontotemporal-dementia disorders (FTDs) Humans Incidence Male Middle Aged Minnesota Neurodegenerative dementia Population-based cohort Sex Factors |
| title | Incidence of frontotemporal disorders in Olmsted County: A population-based study |
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