Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Diseases Caused by TTC7A Deficiency

Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Diseases Caused by TTC7A Deficiency

In a screen of drugs, leflunomide was identified as an agent that might be used to treat patients with intestinal defects caused by mutations in the TTC7A gene.

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Veröffentlicht in:Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2019-11, Vol.158 (4), p.1000-1015
Hauptverfasser: Jardine, Sasha, Anderson, Sierra, Babcock, Stephen, Leung, Gabriella, Pan, Jie, Dhingani, Neel, Warner, Neil, Guo, Conghui, Siddiqui, Iram, Kotlarz, Daniel, Dowling, James J, Melnyk, Roman, Snapper, Scott B, Klein, Christoph, Thiagarajah, Jay R, Muise, Aleixo M
Format: Artikel
Sprache:eng
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Zusammenfassung:In a screen of drugs, leflunomide was identified as an agent that might be used to treat patients with intestinal defects caused by mutations in the TTC7A gene.
ISSN:0016-5085
1528-0012
DOI:10.1053/j.gastro.2019.11.019