Diffusion Tensor MR Imaging and Comparative Histology of Glioma Engrafted in the Rat Spinal Cord
MR imaging using contrast material derived from the diffusion of tissue water was tested for its ability to provide a nondestructive histologic analysis of tumor morphology. An apparent diffusion tensor MR image of a glioma engrafted within a rat spinal cord was generated in which fiber orientation...
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| Veröffentlicht in: | American journal of neuroradiology : AJNR 1999-04, Vol.20 (4), p.713-716 |
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| container_title | American journal of neuroradiology : AJNR |
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| creator | Inglis, Ben A Neubauer, Debbie Yang, Lei Plant, Dan Mareci, Thomas H Muir, David |
| description | MR imaging using contrast material derived from the diffusion of tissue water was tested for its ability to provide a nondestructive histologic analysis of tumor morphology. An apparent diffusion tensor MR image of a glioma engrafted within a rat spinal cord was generated in which fiber orientation in three dimensions was displayed in color. This imaging method clearly separated tumor from host white and gray matter and corresponded well with conventional histologic microscopy. |
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An apparent diffusion tensor MR image of a glioma engrafted within a rat spinal cord was generated in which fiber orientation in three dimensions was displayed in color. This imaging method clearly separated tumor from host white and gray matter and corresponded well with conventional histologic microscopy.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>PMID: 10319987</identifier><identifier>CODEN: AAJNDL</identifier><language>eng</language><publisher>Oak Brook, IL: Am Soc Neuroradiology</publisher><subject>Animals ; Biological and medical sciences ; Body Water ; Coloring Agents ; Contrast Media ; Diffusion ; Glioma - pathology ; Image Processing, Computer-Assisted - methods ; Investigative techniques, diagnostic techniques (general aspects) ; Linear Models ; Magnetic Resonance Imaging - methods ; Medical sciences ; Multivariate Analysis ; Neoplasm Transplantation ; Nerve Fibers - pathology ; Nervous system ; Neurology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Rats ; Rats, Sprague-Dawley ; Spinal Cord - pathology ; Spinal Cord Neoplasms - pathology ; Spine ; Tumors of the nervous system. 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An apparent diffusion tensor MR image of a glioma engrafted within a rat spinal cord was generated in which fiber orientation in three dimensions was displayed in color. This imaging method clearly separated tumor from host white and gray matter and corresponded well with conventional histologic microscopy.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Water</subject><subject>Coloring Agents</subject><subject>Contrast Media</subject><subject>Diffusion</subject><subject>Glioma - pathology</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Linear Models</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Transplantation</subject><subject>Nerve Fibers - pathology</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Spinal Cord - pathology</subject><subject>Spinal Cord Neoplasms - pathology</subject><subject>Spine</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkFtr3DAQhU1oaDZJ_0LQQ9s3g26WrJdC2eYGCYFcIG_KrCXbKrK0lbxZ8u8ryCZtnubAfHMOc_aqBVFM1KpRj5-qBSaqqQXB7UF1mPNvjHGjJP1cHRDMiFKtXFRPv1zfb7KLAd3bkGNC17focoLBhQFBMGgZpzUkmN2zRRcuz9HH4QXFHp17FydAp2FI0M_WIBfQPFp0CzO6W7sAvtwmc1zt9-Cz_bKbR9XD2en98qK-ujm_XP68qkdGyVwb0YGhitFWAmm4aI0oGpsWQ88pprzI8pqi2IK0mKsVa_GKG9o1qmsZZ0fVj1ff9WY1WdPZMCfwep3cBOlFR3D64ya4UQ_xWUvciFJUMfi-M0jxz8bmWU8ud9Z7CDZushZKco6xLODJ_0nvEW-lFuDrDoDcge8ThM7lf5wUSnBRsG-v2OiGceuS1XkC74sr0dvtlmLNtSSM_QXWa43m</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Inglis, Ben A</creator><creator>Neubauer, Debbie</creator><creator>Yang, Lei</creator><creator>Plant, Dan</creator><creator>Mareci, Thomas H</creator><creator>Muir, David</creator><general>Am Soc Neuroradiology</general><general>American Society of Neuroradiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990401</creationdate><title>Diffusion Tensor MR Imaging and Comparative Histology of Glioma Engrafted in the Rat Spinal Cord</title><author>Inglis, Ben A ; Neubauer, Debbie ; Yang, Lei ; Plant, Dan ; Mareci, Thomas H ; Muir, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h321t-d6cad293287a15468d63280d80af420240d8193920ea7e049b380b4d2c59c8343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Water</topic><topic>Coloring Agents</topic><topic>Contrast Media</topic><topic>Diffusion</topic><topic>Glioma - pathology</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Linear Models</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Transplantation</topic><topic>Nerve Fibers - pathology</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Spinal Cord - pathology</topic><topic>Spinal Cord Neoplasms - pathology</topic><topic>Spine</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inglis, Ben A</creatorcontrib><creatorcontrib>Neubauer, Debbie</creatorcontrib><creatorcontrib>Yang, Lei</creatorcontrib><creatorcontrib>Plant, Dan</creatorcontrib><creatorcontrib>Mareci, Thomas H</creatorcontrib><creatorcontrib>Muir, David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inglis, Ben A</au><au>Neubauer, Debbie</au><au>Yang, Lei</au><au>Plant, Dan</au><au>Mareci, Thomas H</au><au>Muir, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diffusion Tensor MR Imaging and Comparative Histology of Glioma Engrafted in the Rat Spinal Cord</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>20</volume><issue>4</issue><spage>713</spage><epage>716</epage><pages>713-716</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><coden>AAJNDL</coden><abstract>MR imaging using contrast material derived from the diffusion of tissue water was tested for its ability to provide a nondestructive histologic analysis of tumor morphology. An apparent diffusion tensor MR image of a glioma engrafted within a rat spinal cord was generated in which fiber orientation in three dimensions was displayed in color. This imaging method clearly separated tumor from host white and gray matter and corresponded well with conventional histologic microscopy.</abstract><cop>Oak Brook, IL</cop><pub>Am Soc Neuroradiology</pub><pmid>10319987</pmid><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0195-6108 |
| ispartof | American journal of neuroradiology : AJNR, 1999-04, Vol.20 (4), p.713-716 |
| issn | 0195-6108 1936-959X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7056019 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Biological and medical sciences Body Water Coloring Agents Contrast Media Diffusion Glioma - pathology Image Processing, Computer-Assisted - methods Investigative techniques, diagnostic techniques (general aspects) Linear Models Magnetic Resonance Imaging - methods Medical sciences Multivariate Analysis Neoplasm Transplantation Nerve Fibers - pathology Nervous system Neurology Radiodiagnosis. Nmr imagery. Nmr spectrometry Rats Rats, Sprague-Dawley Spinal Cord - pathology Spinal Cord Neoplasms - pathology Spine Tumors of the nervous system. Phacomatoses |
| title | Diffusion Tensor MR Imaging and Comparative Histology of Glioma Engrafted in the Rat Spinal Cord |
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