Diffusion Tensor MR Imaging and Comparative Histology of Glioma Engrafted in the Rat Spinal Cord

MR imaging using contrast material derived from the diffusion of tissue water was tested for its ability to provide a nondestructive histologic analysis of tumor morphology. An apparent diffusion tensor MR image of a glioma engrafted within a rat spinal cord was generated in which fiber orientation...

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Veröffentlicht in:	American journal of neuroradiology : AJNR 1999-04, Vol.20 (4), p.713-716
Hauptverfasser:	Inglis, Ben A, Neubauer, Debbie, Yang, Lei, Plant, Dan, Mareci, Thomas H, Muir, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Water Coloring Agents Contrast Media Diffusion Glioma - pathology Image Processing, Computer-Assisted - methods Investigative techniques, diagnostic techniques (general aspects) Linear Models Magnetic Resonance Imaging - methods Medical sciences Multivariate Analysis Neoplasm Transplantation Nerve Fibers - pathology Nervous system Neurology Radiodiagnosis. Nmr imagery. Nmr spectrometry Rats Rats, Sprague-Dawley Spinal Cord - pathology Spinal Cord Neoplasms - pathology Spine Tumors of the nervous system. Phacomatoses
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Zusammenfassung:	MR imaging using contrast material derived from the diffusion of tissue water was tested for its ability to provide a nondestructive histologic analysis of tumor morphology. An apparent diffusion tensor MR image of a glioma engrafted within a rat spinal cord was generated in which fiber orientation in three dimensions was displayed in color. This imaging method clearly separated tumor from host white and gray matter and corresponded well with conventional histologic microscopy.
ISSN:	0195-6108 1936-959X