Dolutegravir for pregnant women living with HIV

Dolutegravir is an integrase inhibitor that works by inhibiting the insertion of HIV DNA into host cells, thereby preventing ongoing viral replication. It is considered an important antiretroviral therapy for many patients living with HIV because it has a favorable adverse effect profile and few drug-drug interactions, is taken once daily as part of a multidrug regimen, and confers a low risk of developing resistance compared with other antiretrovirals. Here, Zipursky and Loutfy examine whether dolutegravir is safe for pregnant women.