Neuroblastoma SH-SY5Y cytotoxicity, anti-amyloidogenic activity and cyclooxygenase inhibition of Lasianthus trichophlebus (Rubiaceae)

The anti-amyloidogenic potential and cyclooxygenase anti-inflammatory activity of Lasianthus trichophlebus extracts were evaluated. The MeOH extract (LTM) and chloroform extract (LTC) exhibited significant cytotoxic inhibition against the neuroblastoma SH-SY5Y cell with an IC 50 of 17.52 μg/mL and 1...

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Veröffentlicht in:	3 Biotech 2020-04, Vol.10 (4), p.152-152, Article 152
Hauptverfasser:	Tan, Mario A., Lagamayo, Mark Wilson D., Alejandro, Grecebio Jonathan D., An, Seong Soo A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Amyloidogenesis anti-inflammatory activity Anti-inflammatory agents Bioinformatics Biomaterials Biotechnology Cancer Research Chemistry Chemistry and Materials Science Chloroform Cyclooxygenase-1 Cyclooxygenase-2 Cytotoxicity enzyme inhibition inhibitory concentration 50 Lasianthus liquid chromatography mass spectrometry methanol Neuroblastoma Neurodegenerative diseases prostaglandin synthase Short Reports Stem Cells Toxicity
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Zusammenfassung:	The anti-amyloidogenic potential and cyclooxygenase anti-inflammatory activity of Lasianthus trichophlebus extracts were evaluated. The MeOH extract (LTM) and chloroform extract (LTC) exhibited significant cytotoxic inhibition against the neuroblastoma SH-SY5Y cell with an IC 50 of 17.52 μg/mL and 12.28 μg/mL, respectively. Thioflavin T assay indicated the LTC extract inhibition (70.56% at 50 μg/mL) to be statistically comparable ( p
ISSN:	2190-572X 2190-5738
DOI:	10.1007/s13205-020-2145-2