Gastrointestinal motility, dysbiosis and opioid-induced tolerance: is there a link?

Studies show that gut microbial dysbiosis induced by chronic opioid use is linked to central opioid tolerance. Here, we suggest that a persistent decrease in gastrointestinal motility by opioids is a primary cause of gut microbial dysbiosis and that improving gastrointestinal transit might be a stra...

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Veröffentlicht in:	Nature reviews. Gastroenterology & hepatology 2019-06, Vol.16 (6), p.323-324
Hauptverfasser:	Akbarali, Hamid I., Dewey, William L.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/1438 692/4020/1503/2745 692/4020/1503/2753 692/4020/2741/2135 Analgesics, Opioid - adverse effects Animals Biomedicine Chronic diseases Comment Complications and side effects Development and progression Digestive system Drug therapy Drug Tolerance Dysbacteriosis Dysbiosis Dysbiosis - etiology Dysbiosis - microbiology Dysbiosis - physiopathology Gastric motility Gastroenterology Gastrointestinal Microbiome - drug effects Gastrointestinal Motility - drug effects Gastrointestinal system Gastrointestinal tract Health aspects Hepatology Humans Intestinal microflora Medicine Medicine & Public Health Microbiota (Symbiotic organisms) Morphine Motility Narcotics Opioids Physiological aspects
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Zusammenfassung:	Studies show that gut microbial dysbiosis induced by chronic opioid use is linked to central opioid tolerance. Here, we suggest that a persistent decrease in gastrointestinal motility by opioids is a primary cause of gut microbial dysbiosis and that improving gastrointestinal transit might be a strategy in preventing opioid analgesic tolerance.
ISSN:	1759-5045 1759-5053 1759-5053
DOI:	10.1038/s41575-019-0150-x