Humanized mice for modeling human infectious disease: challenges, progress, and outlook
Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vacci...
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| Veröffentlicht in: | Cell host & microbe 2009-07, Vol.6 (1), p.5-9 |
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| creator | Legrand, Nicolas Ploss, Alexander Balling, Rudi Becker, Pablo D Borsotti, Chiara Brezillon, Nicolas Debarry, Jennifer de Jong, Ype Deng, Hongkui Di Santo, James P Eisenbarth, Stephanie Eynon, Elizabeth Flavell, Richard A Guzman, Carlos A Huntington, Nicholas D Kremsdorf, Dina Manns, Michael P Manz, Markus G Mention, Jean-Jacques Ott, Michael Rathinam, Chozhavendan Rice, Charles M Rongvaux, Anthony Stevens, Sean Spits, Hergen Strick-Marchand, Hélène Takizawa, Hitoshi van Lent, Anja U Wang, Chengyan Weijer, Kees Willinger, Tim Ziegler, Patrick |
| description | Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases. |
| doi_str_mv | 10.1016/j.chom.2009.06.006 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1931-3128 |
| ispartof | Cell host & microbe, 2009-07, Vol.6 (1), p.5-9 |
| issn | 1931-3128 1934-6069 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7038630 |
| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Biomedical Research - trends Communicable Diseases Disease Models, Animal Humans Mice |
| title | Humanized mice for modeling human infectious disease: challenges, progress, and outlook |
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