Humanized mice for modeling human infectious disease: challenges, progress, and outlook

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vacci...

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Veröffentlicht in:	Cell host & microbe 2009-07, Vol.6 (1), p.5-9
Hauptverfasser:	Legrand, Nicolas, Ploss, Alexander, Balling, Rudi, Becker, Pablo D, Borsotti, Chiara, Brezillon, Nicolas, Debarry, Jennifer, de Jong, Ype, Deng, Hongkui, Di Santo, James P, Eisenbarth, Stephanie, Eynon, Elizabeth, Flavell, Richard A, Guzman, Carlos A, Huntington, Nicholas D, Kremsdorf, Dina, Manns, Michael P, Manz, Markus G, Mention, Jean-Jacques, Ott, Michael, Rathinam, Chozhavendan, Rice, Charles M, Rongvaux, Anthony, Stevens, Sean, Spits, Hergen, Strick-Marchand, Hélène, Takizawa, Hitoshi, van Lent, Anja U, Wang, Chengyan, Weijer, Kees, Willinger, Tim, Ziegler, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical Research - trends Communicable Diseases Disease Models, Animal Humans Mice
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.
ISSN:	1931-3128 1934-6069
DOI:	10.1016/j.chom.2009.06.006