The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth

The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth

The placenta is metabolically active and supports the growth of the fetus. We hypothesize that deficits in the capacity of the placenta to maintain bioenergetic and metabolic stability during pregnancy may result in spontaneous preterm birth (SPTB). To explore this hypothesis, we performed a nested...

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Veröffentlicht in:International journal of molecular sciences 2020-02, Vol.21 (3), p.1043
Hauptverfasser: Elshenawy, Summer, Pinney, Sara E, Stuart, Tami, Doulias, Paschalis-Thomas, Zura, Gabriella, Parry, Samuel, Elovitz, Michal A, Bennett, Michael J, Bansal, Amita, Strauss, 3rd, Jerome F, Ischiropoulos, Harry, Simmons, Rebecca A
Format: Artikel
Sprache:eng
Schlagworte:
Biosynthesis
Birth
Estrogens
Fatty acids
Fetuses
Gestation
Gestational age
Mass spectrometry
Mass spectroscopy
Metabolism
Metabolites
Metabolomics
Oxidation
Oxidative stress
Palmitic acid
Placenta
Polyamines
Preeclampsia
Premature birth
Principal components analysis
Prostaglandins
Sphingolipids
Womens health
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Zusammenfassung:The placenta is metabolically active and supports the growth of the fetus. We hypothesize that deficits in the capacity of the placenta to maintain bioenergetic and metabolic stability during pregnancy may result in spontaneous preterm birth (SPTB). To explore this hypothesis, we performed a nested cased control study of metabolomic signatures in placentas from women with SPTB (
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21031043