An Evaluation of the Effects of Betahistine and Dimenhydrinate on Posterior Canal Benign Paroxysmal Positional Vertigo
Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular system disease causing dizziness. It occurs more in the 5th decade of life and affects the posterior canal in 90% of the patients. The most effective treatment method is canalith repositioning (CRP) maneuver. The ai...
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Veröffentlicht in: | Turkish Archives of Otorhinolaryngology 2019-12, Vol.57 (4), p.191-196 |
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description | Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular system disease causing dizziness. It occurs more in the 5th decade of life and affects the posterior canal in 90% of the patients. The most effective treatment method is canalith repositioning (CRP) maneuver. The aim of this study is to evaluate the effects of betahistine and dimenhydrinate therapies in addition to CRP maneuver on BPPV patients.
The study included 64 patients who had complaints of dizziness and were diagnosed with BPPV by their history and provocation maneuvers. The patients were divided into two groups. In Group 1, only repositioning maneuver was performed. Group 2 was divided into two subgroups. In Group 2a, repositioning maneuver was performed and betahistine 24 mg twice daily was given for 10 days. In Group 2b, repositioning maneuver was performed and dimenhydrinate 50 mg once daily was given for five days. On the 10
day, all patients were reexamined, and provocation maneuver was performed. Dizziness handicap inventory (DHI) was completed and outcomes were reviewed for therapeutic efficacy.
Mean DHI scores in all patient groups statistically significantly decreased from a pre-treatment level of 52.16 (range, 20-100) to a post-treatment level of 17.84 (range, 0-78) (p |
doi_str_mv | 10.5152/tao.2019.4185 |
format | Article |
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The study included 64 patients who had complaints of dizziness and were diagnosed with BPPV by their history and provocation maneuvers. The patients were divided into two groups. In Group 1, only repositioning maneuver was performed. Group 2 was divided into two subgroups. In Group 2a, repositioning maneuver was performed and betahistine 24 mg twice daily was given for 10 days. In Group 2b, repositioning maneuver was performed and dimenhydrinate 50 mg once daily was given for five days. On the 10
day, all patients were reexamined, and provocation maneuver was performed. Dizziness handicap inventory (DHI) was completed and outcomes were reviewed for therapeutic efficacy.
Mean DHI scores in all patient groups statistically significantly decreased from a pre-treatment level of 52.16 (range, 20-100) to a post-treatment level of 17.84 (range, 0-78) (p<0.001). No statistically significant differences were found in terms of DHI scores between Group 1 (repositioning maneuver only) and Group 2 (repositioning maneuver plus betahistine or dimenhydrinate).
The most effective treatment method of BPPV is repositioning maneuver. Addition of betahistine or dimenhydrinate pharmacotherapy to repositioning maneuver did not show superiority to treatment with repositioning maneuvers alone.</description><identifier>ISSN: 2667-7466</identifier><identifier>ISSN: 2667-7474</identifier><identifier>EISSN: 2667-7474</identifier><identifier>DOI: 10.5152/tao.2019.4185</identifier><identifier>PMID: 32128517</identifier><language>eng</language><publisher>Turkey: Turkish Otorhinolaryngology Head and Neck Surgery Society</publisher><subject>benign paroxysmal positional vertigo ; canalith repositioning maneuver ; epley maneuver ; Original Investigation ; pharmacotherapy</subject><ispartof>Turkish Archives of Otorhinolaryngology, 2019-12, Vol.57 (4), p.191-196</ispartof><rights>Copyright 2019 by Official Journal of the Turkish Society of Otorhinolaryngology and Head and Neck Surgery.</rights><rights>Copyright 2019 by Official Journal of the Turkish Society of Otorhinolaryngology and Head and Neck Surgery 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-c47b90329605c3a99340c63cc8788f5cef812dfb90557eca23d3d0374f52a9683</citedby><orcidid>0000-0002-7710-441X ; 0000-0001-6254-372X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032557/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032557/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32128517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inan, Hakki Caner</creatorcontrib><creatorcontrib>Kirac, Merve</creatorcontrib><creatorcontrib>Department of Otorhinolaryngology, Erzincan University School of Medicine, Erzincan, Turkey</creatorcontrib><title>An Evaluation of the Effects of Betahistine and Dimenhydrinate on Posterior Canal Benign Paroxysmal Positional Vertigo</title><title>Turkish Archives of Otorhinolaryngology</title><addtitle>Turk Arch Otorhinolaryngol</addtitle><description>Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular system disease causing dizziness. It occurs more in the 5th decade of life and affects the posterior canal in 90% of the patients. The most effective treatment method is canalith repositioning (CRP) maneuver. The aim of this study is to evaluate the effects of betahistine and dimenhydrinate therapies in addition to CRP maneuver on BPPV patients.
The study included 64 patients who had complaints of dizziness and were diagnosed with BPPV by their history and provocation maneuvers. The patients were divided into two groups. In Group 1, only repositioning maneuver was performed. Group 2 was divided into two subgroups. In Group 2a, repositioning maneuver was performed and betahistine 24 mg twice daily was given for 10 days. In Group 2b, repositioning maneuver was performed and dimenhydrinate 50 mg once daily was given for five days. On the 10
day, all patients were reexamined, and provocation maneuver was performed. Dizziness handicap inventory (DHI) was completed and outcomes were reviewed for therapeutic efficacy.
Mean DHI scores in all patient groups statistically significantly decreased from a pre-treatment level of 52.16 (range, 20-100) to a post-treatment level of 17.84 (range, 0-78) (p<0.001). No statistically significant differences were found in terms of DHI scores between Group 1 (repositioning maneuver only) and Group 2 (repositioning maneuver plus betahistine or dimenhydrinate).
The most effective treatment method of BPPV is repositioning maneuver. Addition of betahistine or dimenhydrinate pharmacotherapy to repositioning maneuver did not show superiority to treatment with repositioning maneuvers alone.</description><subject>benign paroxysmal positional vertigo</subject><subject>canalith repositioning maneuver</subject><subject>epley maneuver</subject><subject>Original Investigation</subject><subject>pharmacotherapy</subject><issn>2667-7466</issn><issn>2667-7474</issn><issn>2667-7474</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkUtvEzEUhS0EolXpki2aP5Dg53hmg1RCoJUqwQLYWrd-JK4mdmW7UfPvuUNKRDd-XJ_7nWsdQt4zulRM8Y8N8pJTNi4lG9Qrcs77Xi-01PL16dz3Z-Sy1ntKKWeaUcnekjPBGR8U0-dkf5W69R6mR2gxpy6Hrm19tw7B21bn62ffYBtri8l3kFz3Je582h5ciQma77DnR67Nl5hLt4IEE3akuMEylPx0qDusoCLOeDz-9qXFTX5H3gSYqr983i_Ir6_rn6vrxe33bzerq9uFlYo2XPXdSAUfe6qsgHEUktpeWDvoYQjK-jAw7gJqlNLeAhdOOCq0DIrD2A_igtwcuS7DvXkocQflYDJE87eQy8YADmQnb9DD9RptmLSSSoVmQgYRnA0yDJYj69OR9fB4t_PO-tQKTC-gL19S3JpN3huNP8D5ELA4AmzJtRYfTr2MmjlPg3maOU8z54n6D_8bntT_0hN_AI4bnUs</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Inan, Hakki Caner</creator><creator>Kirac, Merve</creator><general>Turkish Otorhinolaryngology Head and Neck Surgery Society</general><general>Galenos Yayincilik</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7710-441X</orcidid><orcidid>https://orcid.org/0000-0001-6254-372X</orcidid></search><sort><creationdate>20191201</creationdate><title>An Evaluation of the Effects of Betahistine and Dimenhydrinate on Posterior Canal Benign Paroxysmal Positional Vertigo</title><author>Inan, Hakki Caner ; Kirac, Merve</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-c47b90329605c3a99340c63cc8788f5cef812dfb90557eca23d3d0374f52a9683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>benign paroxysmal positional vertigo</topic><topic>canalith repositioning maneuver</topic><topic>epley maneuver</topic><topic>Original Investigation</topic><topic>pharmacotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inan, Hakki Caner</creatorcontrib><creatorcontrib>Kirac, Merve</creatorcontrib><creatorcontrib>Department of Otorhinolaryngology, Erzincan University School of Medicine, Erzincan, Turkey</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Turkish Archives of Otorhinolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inan, Hakki Caner</au><au>Kirac, Merve</au><aucorp>Department of Otorhinolaryngology, Erzincan University School of Medicine, Erzincan, Turkey</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Evaluation of the Effects of Betahistine and Dimenhydrinate on Posterior Canal Benign Paroxysmal Positional Vertigo</atitle><jtitle>Turkish Archives of Otorhinolaryngology</jtitle><addtitle>Turk Arch Otorhinolaryngol</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>57</volume><issue>4</issue><spage>191</spage><epage>196</epage><pages>191-196</pages><issn>2667-7466</issn><issn>2667-7474</issn><eissn>2667-7474</eissn><abstract>Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular system disease causing dizziness. It occurs more in the 5th decade of life and affects the posterior canal in 90% of the patients. The most effective treatment method is canalith repositioning (CRP) maneuver. The aim of this study is to evaluate the effects of betahistine and dimenhydrinate therapies in addition to CRP maneuver on BPPV patients.
The study included 64 patients who had complaints of dizziness and were diagnosed with BPPV by their history and provocation maneuvers. The patients were divided into two groups. In Group 1, only repositioning maneuver was performed. Group 2 was divided into two subgroups. In Group 2a, repositioning maneuver was performed and betahistine 24 mg twice daily was given for 10 days. In Group 2b, repositioning maneuver was performed and dimenhydrinate 50 mg once daily was given for five days. On the 10
day, all patients were reexamined, and provocation maneuver was performed. Dizziness handicap inventory (DHI) was completed and outcomes were reviewed for therapeutic efficacy.
Mean DHI scores in all patient groups statistically significantly decreased from a pre-treatment level of 52.16 (range, 20-100) to a post-treatment level of 17.84 (range, 0-78) (p<0.001). No statistically significant differences were found in terms of DHI scores between Group 1 (repositioning maneuver only) and Group 2 (repositioning maneuver plus betahistine or dimenhydrinate).
The most effective treatment method of BPPV is repositioning maneuver. Addition of betahistine or dimenhydrinate pharmacotherapy to repositioning maneuver did not show superiority to treatment with repositioning maneuvers alone.</abstract><cop>Turkey</cop><pub>Turkish Otorhinolaryngology Head and Neck Surgery Society</pub><pmid>32128517</pmid><doi>10.5152/tao.2019.4185</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7710-441X</orcidid><orcidid>https://orcid.org/0000-0001-6254-372X</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | benign paroxysmal positional vertigo canalith repositioning maneuver epley maneuver Original Investigation pharmacotherapy |
title | An Evaluation of the Effects of Betahistine and Dimenhydrinate on Posterior Canal Benign Paroxysmal Positional Vertigo |
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