A clinical decision support tool may help to optimise vedolizumab therapy in Crohn’s disease

Summary Background A clinical decision support tool (CDST) has been validated for predicting treatment effectiveness of vedolizumab (VDZ) in Crohn’s disease. Aim To assess the utility of this CDST for predicting exposure‐efficacy and disease outcomes. Methods Using data from three independent datase...

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Veröffentlicht in:	Alimentary pharmacology & therapeutics 2020-03, Vol.51 (5), p.553-564
Hauptverfasser:	Dulai, Parambir S., Amiot, Aurelien, Peyrin‐Biroulet, Laurent, Jairath, Vipul, Serrero, Melanie, Filippi, Jerome, Singh, Siddharth, Pariente, Benjamin, Loftus, Edward V., Roblin, Xavier, Kane, Sunanda, Buisson, Anthony, Siegel, Corey A., Bouhnik, Yoram, Sandborn, William J., Lasch, Karen, Rosario, Maria, Feagan, Brian G., Bojic, Daniela, Trang‐Poisson, Caroline, Shen, Bo, Altwegg, Romain, Sands, Bruce E., Colombel, Jean‐Frederic, Carbonnel, Franck, Kochhar, Gursimran, Meserve, Joseph, Barsky, Maria, Boland, Brigid S, Gagniere, Charlotte, Bigard, Marc‐Andre, Zallot, Camille, Grimaud, Jean‐Charles, Hebuterne, Xavier, Nachury, Maria, Desreumaux, Pierre, Del Tedesco, Emilie, Bommelaer, Gilles, Koliani‐Pace, Jenna L, Stefanescu, Carmen, Boureille, Arnaud, Hirten, Robert, Ungaro, Ryan, Vaysse, Thibaud, Bohm, Matthew, Varma, Sashidhar, Fischer, Monika, Hudesman, David, Chang, Shannon, Bourrier, Anne, Seksik, Philippe, Beaugerie, Laurent, Cosnes, Jacques, Sokol, Harry, Landman, Cecilia, Lukin, Dana, Weiss, Aaron, Marteau, Philippe, Dray, Xavier, Nancey, Stephane, Boschetti, Gilles, Laharie, David, Poullenot, Florian, Allez, Matthieu, Gornet, Jean‐Marc, Baudry, Clautilde, Savoye, Guillaume, Moreau, Jacques, Vuitton, Lucine, Koch, Stephane, Viennot, Stephanie, Aubourg, Alexandre, Picon, Laurence, Pelletier, Anne‐Laure, Sickersen, Gaelle, Bouguen, Guillaume, Abitbol, Vered, Chaussade, Stanislas, Nahon, Stephane, Fumery, Mathurin, Winkfield, Betsy, Brixi‐Benmansour, Hedia, Gincul, Rodica, Barberis, Jean‐Christophe, Bonaz, Bruno, Michiels, Christophe, Zerbib, Frank, Bourrier de Beauregard, Marie, Locher, Christophe, Davin‐Couve, Sophie, Poirette, Armelle, Guillem, Laurence, Stetiu‐Mocanu, Monica, Philippe, Beau, Beorchia, Sylvain, Al Qaddi, Jawad, Swaminath, Arun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Algorithms Antibodies, Monoclonal, Humanized - therapeutic use Calibration Cohort Studies Crohn Disease - drug therapy Crohn Disease - epidemiology Decision Support Systems, Clinical Drug Monitoring - methods Drug Monitoring - standards Female Gastrointestinal Agents - therapeutic use Humans Life Sciences Male Middle Aged Optimising Vedolizumab in Crohn's Disease Original Patient Selection Patients Remission Surgery Treatment Outcome Young Adult
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Zusammenfassung:	Summary Background A clinical decision support tool (CDST) has been validated for predicting treatment effectiveness of vedolizumab (VDZ) in Crohn’s disease. Aim To assess the utility of this CDST for predicting exposure‐efficacy and disease outcomes. Methods Using data from three independent datasets (GEMINI, GETAID and VICTORY), we assessed clinical remission rates and measured VDZ exposure, rapidity of onset of action, response to dose optimisation and progression to surgery by CDST‐defined response groups (low, intermediate and high). Results A linear relationship existed between CDST‐defined groups, measured VDZ exposure, rapidity of onset of action and efficacy in GEMINI through week 52 (P
ISSN:	0269-2813 1365-2036
DOI:	10.1111/apt.15609