Comparison of topical antiaging creams in the management of lateral canthal lines

Objective This study compared an antiaging treatment with two currently marketed cosmetic antiaging products for the treatment of lateral canthal lines ("crow's feet"). Methods Healthy female volunteers (72) aged of 54.6 years (mean) having fine‐to‐moderate wrinkles in the lateral canthal areas were randomized to one of three treatments applied daily over 28 days: Group A (Purgenesis™ Day Cream, Purgenesis™ Eye Cream, and Purgenesis™ Night Cream); Group B (Prevage® Eye Lotion, Prevage® Day Cream, and Prevage® Night Cream); or Group C (La Mer® Eye Balm, Crème de La Mer®, and La Mer® Night Cream). The effects on anti‐wrinkle properties and for sensory attributes and general performance were evaluated on Days 1, 7, and 28. Results Skin hydration improved significantly at all time points in Groups A and B, and at Day 28 in Group C. Group A patients experienced significant improvements in measured skin elasticity parameters at Day 28; extensibility and maximum amplitude were significantly better at Day 28 in Groups B and C. Benefits were also seen in profilometric parameters with statistical significance only in Group A Volunteer tolerance was good with all three treatments, although moderate and high levels of adverse events were numerically higher in Group B than in Groups A or C, and levels of slight discomfort were significantly more prevalent in Group B. Conclusion The Purgenesis™ antiaging treatment significantly improved skin hydration, elasticity, and profilometry parameters during a 28‐day study. This therapy was found to be well tolerated and effective in countering the cutaneous signs of aging.