Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma

Whether an increase in the dose of inhaled glucocorticoids or the addition of long-acting beta-agonists will lead to better outcomes in black children with moderate asthma is not known. Surprisingly, the data showed that increased doses of an inhaled glucocorticoid were as effective as addition of a...

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Veröffentlicht in:	The New England journal of medicine 2019-09, Vol.381 (13), p.1227-1239
Hauptverfasser:	Wechsler, Michael E, Szefler, Stanley J, Ortega, Victor E, Pongracic, Jacqueline A, Chinchilli, Vernon, Lima, John J, Krishnan, Jerry A, Kunselman, Susan J, Mauger, David, Bleecker, Eugene R, Bacharier, Leonard B, Beigelman, Avraham, Benson, Mindy, Blake, Kathryn V, Cabana, Michael D, Cardet, Juan-Carlos, Castro, Mario, Chmiel, James F, Covar, Ronina, Denlinger, Loren, DiMango, Emily, Fitzpatrick, Anne M, Gentile, Deborah, Grossman, Nicole, Holguin, Fernando, Jackson, Daniel J, Kumar, Harsha, Kraft, Monica, LaForce, Craig F, Lang, Jason, Lazarus, Stephen C, Lemanske, Robert F, Long, Dayna, Lugogo, Njira, Martinez, Fernando, Meyers, Deborah A, Moore, Wendy C, Moy, James, Naureckas, Edward, Olin, J. Tod, Peters, Stephen P, Phipatanakul, Wanda, Que, Loretta, Raissy, Hengameh, Robison, Rachel G, Ross, Kristie, Sheehan, William, Smith, Lewis J, Solway, Julian, Sorkness, Christine A, Sullivan-Vedder, Lisa, Wenzel, Sally, White, Steven, Israel, Elliot
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adolescent Adolescents Adrenergic beta-2 Receptor Agonists - administration & dosage Adult African Americans Asthma Asthma - drug therapy Bronchodilator Agents - administration & dosage Child Child, Preschool Children Clinical trials Creatinine Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Double-blind studies Drug Combinations Drug dosages Female Fluticasone Fluticasone - administration & dosage Glucocorticoids Glucocorticoids - administration & dosage Grandparents Humans Male Morbidity Pharmaceuticals Propionic acid Prospective Studies Respiratory function Salmeterol Salmeterol Xinafoate - administration & dosage Teenagers
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Zusammenfassung:	Whether an increase in the dose of inhaled glucocorticoids or the addition of long-acting beta-agonists will lead to better outcomes in black children with moderate asthma is not known. Surprisingly, the data showed that increased doses of an inhaled glucocorticoid were as effective as addition of a LABA.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1905560