A cryptic imatinib-sensitive G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia

•Targeted RNA sequencing detected a cryptic G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia and normal FISH studies.•Consistent with the patient's response to imatinib, we demonstrate this rearrangement is oncogenic and sensitive to TKI in cell culture.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood advances 2020-02, Vol.4 (3), p.445-448
Hauptverfasser:	Jan, Max, Grinshpun, Daniel E., Villalba, Julian A., Dal Cin, Paola, Sykes, David B., Iafrate, A. John, Ebert, Benjamin L., Hobbs, Gabriela S., Nardi, Valentina
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA Helicases - genetics Eosinophilia - drug therapy Eosinophilia - genetics Exceptional Case Report Humans Imatinib Mesylate - therapeutic use Male Neoplasms Poly-ADP-Ribose Binding Proteins - genetics Receptor, Platelet-Derived Growth Factor beta - genetics RNA Helicases - genetics RNA Recognition Motif Proteins - genetics Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	•Targeted RNA sequencing detected a cryptic G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia and normal FISH studies.•Consistent with the patient's response to imatinib, we demonstrate this rearrangement is oncogenic and sensitive to TKI in cell culture.
ISSN:	2473-9529 2473-9537
DOI:	10.1182/bloodadvances.2019001182