Interferon Gamma Test for the Detection of Mycobacterium tuberculosis Complex Infection in Macaca mulatta and Other Nonhuman Primates

We have formatted an assay to detect Mycobacterium tuberculosis complex infections of nonhuman primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimen...

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Veröffentlicht in:Journal of medical primatology 2019-05, Vol.48 (4), p.260-263
Hauptverfasser: Yee, JoAnn L., Prongay, Kamm, Miles, Brodie, Smedley, Jeremy, Hansen, Scott G., Axthelm, Michael K., Ardeshir, Amir, Van Rompay, Koen K. A., Timmel, Gregory, Roberts, Jeffrey A.
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container_end_page 263
container_issue 4
container_start_page 260
container_title Journal of medical primatology
container_volume 48
creator Yee, JoAnn L.
Prongay, Kamm
Miles, Brodie
Smedley, Jeremy
Hansen, Scott G.
Axthelm, Michael K.
Ardeshir, Amir
Van Rompay, Koen K. A.
Timmel, Gregory
Roberts, Jeffrey A.
description We have formatted an assay to detect Mycobacterium tuberculosis complex infections of nonhuman primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M. tuberculosis distinguished infected versus uninfected animals.
doi_str_mv 10.1111/jmp.12420
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title Interferon Gamma Test for the Detection of Mycobacterium tuberculosis Complex Infection in Macaca mulatta and Other Nonhuman Primates
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