Interferon Gamma Test for the Detection of Mycobacterium tuberculosis Complex Infection in Macaca mulatta and Other Nonhuman Primates

We have formatted an assay to detect Mycobacterium tuberculosis complex infections of nonhuman primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M. tuberculosis distinguished infected versus uninfected animals.