A single bout of resistance exercise improves postprandial lipid metabolism in overweight/obese men with prediabetes

Aims/hypothesis Prediabetes is associated with postprandial hypertriacylglycerolaemia. Resistance exercise acutely lowers postprandial plasma triacylglycerol (TG); however, the changes in lipid metabolism that mediate this reduction are poorly understood. The aim of this study was to identify the co...

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Veröffentlicht in:	Diabetologia 2020-03, Vol.63 (3), p.611-623
Hauptverfasser:	Bittel, Adam J., Bittel, Daniel C., Mittendorfer, Bettina, Patterson, Bruce W., Okunade, Adewole L., Yoshino, Jun, Porter, Lane C., Abumrad, Nada A., Reeds, Dominic N., Cade, W. Todd
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adult Aged Body weight Calorimetry Cardiovascular diseases Chylomicrons - blood Chylomicrons - metabolism Diabetes mellitus (non-insulin dependent) Exercise Fatty Acids, Nonesterified - blood Fatty Acids, Nonesterified - metabolism Gene expression Glycerol Human Physiology Humans Insulin Resistance - physiology Internal Medicine Lipid metabolism Lipid Metabolism - physiology Lipid peroxidation Lipids Lipolysis Lipoproteins, VLDL - blood Lipoproteins, VLDL - metabolism Male Medicine Medicine & Public Health Mens health Metabolic Diseases Metabolism Middle Aged Mitochondria Muscle, Skeletal - metabolism Musculoskeletal system Obesity Obesity - complications Obesity - metabolism Obesity - therapy Overweight Overweight - complications Overweight - metabolism Overweight - therapy Oxidation Palmitic acid Postprandial Period - physiology Prediabetic State - complications Prediabetic State - metabolism Prediabetic State - therapy Resistance Training - methods Skeletal muscle Treatment Outcome Triglycerides - blood Triglycerides - metabolism
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Zusammenfassung:	Aims/hypothesis Prediabetes is associated with postprandial hypertriacylglycerolaemia. Resistance exercise acutely lowers postprandial plasma triacylglycerol (TG); however, the changes in lipid metabolism that mediate this reduction are poorly understood. The aim of this study was to identify the constitutive metabolic mechanisms underlying the changes in postprandial lipid metabolism after resistance exercise in obese men with prediabetes. Methods We evaluated the effect of a single bout of whole-body resistance exercise (seven exercises, three sets, 10–12 repetitions at 80% of one-repetition maximum) on postprandial lipid metabolism in ten middle-aged (50 ± 9 years), overweight/obese (BMI: 33 ± 3 kg/m 2 ), sedentary men with prediabetes (HbA 1c >38 but 5.7% but 5.6 mmol/l but 7.8 mmol/l but
ISSN:	0012-186X 1432-0428
DOI:	10.1007/s00125-019-05070-x