(In)Fertility and Oxidative Stress: New Insights into Novel Redox Mechanisms Controlling Fundamental Reproductive Processes

At the subcellular level, excessive ROS production dysregulates cell signalling networks and promotes oxidation of DNA, lipids, and proteins, which can ultimately lead to cellular dysfunction by functionally altering subcellular structures such as the endoplasmatic reticulum or the mitochondria, to name a few. [...]studies focusing on causal connections between ROS, infertility, reproductive ageing, pregnancy-related pathologies, and cellular stress are of main interest. [...]the possibility that an abnormal uterine microenvironment, already present before or at the time of implantation, jeopardizes fertility and increases the risk for the development of pregnancy-related complications was reviewed by S. Mendes et al. [...]they thank the editorial board and all the staff for the opportunity and support that made this special issue publication possible.