m6A facilitates YTHDF‐independent phase separation

m6A facilitates YTHDF‐independent phase separation

N6‐methyladenosine (m6A) is one of the most abundant messenger RNA (mRNA) modifications in eukaryotes and is involved in various key processes of RNA metabolism. In this issue of Nature, Ries et al (2019) described the fundamental features of m6A modification of mRNAs in regulating the composition o...

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Veröffentlicht in:Journal of cellular and molecular medicine 2020-01, Vol.24 (2), p.2070-2072
Hauptverfasser: Liu, Si‐Yu, Feng, Yi, Wu, Jun-Jie, Zou, Ming-Li, Sun, Zi-Li, Li, Xia, Yuan, Feng‐Lai
Format: Artikel
Sprache:eng
Schlagworte:
Eukaryotes
Gene expression
Heat
Kinases
Localization
m6A
Metabolism
methylation
N6-methyladenosine
Oxidative stress
phase separation
Phase transitions
Physiology
Proteins
Short Communication
Short Communications
Signal transduction
Stem cells
YTHDF protein
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Zusammenfassung:N6‐methyladenosine (m6A) is one of the most abundant messenger RNA (mRNA) modifications in eukaryotes and is involved in various key processes of RNA metabolism. In this issue of Nature, Ries et al (2019) described the fundamental features of m6A modification of mRNAs in regulating the composition of the phase‐separated transcriptome on the basis of number and distribution, and provide strong evidence that m6A plays a role in regulating phase separation in cells.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.14847