Effect of a Behavioral Intervention to Increase Vegetable Consumption on Cancer Progression Among Men With Early-Stage Prostate Cancer: The MEAL Randomized Clinical Trial

Effect of a Behavioral Intervention to Increase Vegetable Consumption on Cancer Progression Among Men With Early-Stage Prostate Cancer: The MEAL Randomized Clinical Trial

IMPORTANCE: Guidelines endorsing vegetable-enriched diets to improve outcomes for prostate cancer survivors are based on expert opinion, preclinical studies, and observational data. OBJECTIVE: To determine the effect of a behavioral intervention that increased vegetable intake on cancer progression...

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Veröffentlicht in:JAMA : the journal of the American Medical Association 2020-01, Vol.323 (2), p.140-148
Hauptverfasser: Parsons, J. Kellogg, Zahrieh, David, Mohler, James L, Paskett, Electra, Hansel, Donna E, Kibel, Adam S, Liu, Heshan, Seisler, Drew K, Natarajan, Loki, White, Martha, Hahn, Olwen, Taylor, John, Hartman, Sheri J, Stroup, Sean P, Van Veldhuizen, Peter, Hall, Lannis, Small, Eric J, Morris, Michael J, Pierce, John P, Marshall, James
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma
Aged
Aged, 80 and over
Antigens
Behavior modification
Biopsy
Clinical trials
Consumption
Counseling
Diet
Disease Progression
Health risks
Humans
Intervention
Male
Middle Aged
Neoplasm Staging
Oncology
Original Investigation
Patients
Population studies
Prostate cancer
Prostate-specific antigen
Prostate-Specific Antigen - blood
Prostatic Neoplasms - diet therapy
Prostatic Neoplasms - pathology
Prostatic Neoplasms - therapy
Telephone
Urology
Vegetables
Watchful Waiting
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Beschreibung
Zusammenfassung:IMPORTANCE: Guidelines endorsing vegetable-enriched diets to improve outcomes for prostate cancer survivors are based on expert opinion, preclinical studies, and observational data. OBJECTIVE: To determine the effect of a behavioral intervention that increased vegetable intake on cancer progression in men with early-stage prostate cancer. DESIGN, SETTING, AND PARTICIPANTS: The Men’s Eating and Living (MEAL) Study (CALGB 70807 [Alliance]) was a randomized clinical trial conducted at 91 US urology and medical oncology clinics that enrolled 478 men aged 50 to 80 years with biopsy-proven prostate adenocarcinoma (International Society of Urological Pathology grade group = 1 in those
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.2019.20207